Alzheimer's disease: encouraging results

Alzheimer's Medicine Works

Svetlana Maslova, Hi-tech+

Scientists have approached the moment when it will be possible to say that a cure for Alzheimer's disease has been found. A major new clinical trial of a new drug demonstrates significant cognitive improvements in patients.

An experimental drug has shown unprecedented results for the treatment of Alzheimer's disease. The drug significantly reduced cognitive decline in patients in the long term.

The drug, called BAN2401, delayed the memory-destroying effects and 18 months after treatment, all patients coped with the cognitive test 30% better than patients with placebo.

The maximum dose of the drug in 81% of patients demonstrated a transition to an amyloid-negative state (the accumulation of amyloid plaques in the brain decreased), and in 47% of patients there was a decrease in cognitive decline.

Scientists call the result unexpected and unprecedented and plan to double-check the data in the third phase of clinical trials, writes Scientific American.

"The data obtained is intriguing. At the same time, the drug confirms its safety, and the result proves its effectiveness," says researcher Ronald Petersen.

However, there are caveats in the study that have yet to be clarified. In an experiment with a high dosage, which was tested on only 161 patients, the drug failed to surpass the placebo. The team plans to verify the ideal therapeutic dose in a new clinical trial and finally confirm the positive effect of treatment.

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