Early and differential

Parkinson's disease can be detected at an early stage by the skin

Svetlana Maslova, Hi-tech+

Scientists have demonstrated the possibility of effective diagnosis of Parkinson's disease by skin biopsy and proved its ability to distinguish the disease from similar conditions with atypical Parkinsonism at an early stage.

Italian researchers from the University of Bologna have found that deposits of phosphorylated alpha-synuclein (p-syn) protein in the skin and brain distinguish patients with Parkinson's disease from patients with symptoms of Parkinsonism — progressive supranuclear palsy (PNP) and corticobasal degeneration (CBD).

The study, which is reported by the IOS Press press release, involved 26 patients with Parkinson's disease, 18 people with PNP and 8 people with CBD. The control group consisted of 26 volunteers. It turned out that all participants with Parkinson's disease had p-syn deposits in the skin, while healthy people and almost all patients with PNP and CBD did not have them. The exception was two people who may have had a mixed pathology with multiple neurodegenerative disorders, the authors said.

"We have shown that the presence of p-syn deposits in the skin accurately distinguishes people with Parkinson's disease from other patients with Parkinsonism. This is especially important for diagnosis at an early stage, since the treatment and prognosis of these conditions are different," concluded co—author Maria Pia Giannocaro.

Article by Giannoccaro et al. The Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome is published in the Journal of Parkinson's Disease

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