Ferroptosis against cancer
The effectiveness of antitumor therapy can be increased with the help of ferroptosis
Alexandra Medvedev, Indicator
Scientists from Russia, Italy and Belgium have shown for the first time that in the early stages of cancer cell death , specific molecules are released along the path of ferroptosis, which contribute to the attraction and maturation of antigen-presenting cells and subsequent activation of the immune response. The article was published in the Journal for Immunotherapy of Cancer (Efimova et al., Vaccination with early ferroptotic cancer cells induces effective antitumor immunity).
The development of malignant neoplasms and their resistance to therapy are largely determined by the withdrawal of tumor cells from immunological control. The use of methods that trigger the death of tumor cells along the immunogenic pathway allows you to activate a specific immune response that enters the fight against malignant cells, which determines the long-term remission or even complete recovery of the patient.
The staff of the Institute of Biology and Biomedicine of UNN together with colleagues from Ghent and Bologna Universities investigated the possibility of increasing the effectiveness of antitumor therapy by activating the recently discovered mechanism of cell death – ferroptosis. The authors have shown that in the early stages of cancer cell death, specific molecules (DAMPs) are released along the path of ferroptosis, which contribute to the attraction and maturation of antigen-presenting cells (dendritic cells) and subsequent activation of the immune response.
"On an animal model of preventive vaccination with such dying tumor cells, a significant slowdown in the growth of an experimental tumor has been established," notes Maria Vedunova, one of the researchers, director of the IBBM of the National Research University.
Currently, researchers continue to actively study the mechanisms of this type of cell death and believe that this experimental approach can be used in the future as a new way to effectively combat tumors that are poorly amenable to traditional therapy.
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