Lipids against demyelination
A group of researchers led by Ruben Lopez-Vales from the Independent University of Barcelona reduced chronic inflammation associated with multiple sclerosis in mice by introducing special lipids that stop inflammation. These mediator substances, responsible for the subsiding of the inflammatory process when it is no longer beneficial, are contained in minimal amounts in people with multiple sclerosis, as well as in animal models of this disease. Their introduction from the outside can become an effective strategy for the treatment of this autoimmune disease.
Acute inflammation is a protective reaction of the body that promotes tissue regeneration after injury. Once the function of inflammation is completed, a number of mechanisms regulated by lipids acting as mediators are responsible for its resolution. Violation of the resolution process leads to uncontrolled inflammation, which damages its own tissues. In multiple sclerosis, the immune cells of the body attack the myelin sheath of the processes of neurons, autoimmune inflammation is persistent and plays a key role in the development of the disease.
The research team achieved a reduction in chronic inflammation associated with multiple sclerosis in a mouse model of the disease by introducing one of the inhibitory lipid mediators of inflammation, maresin-1 (ma crophage mediator in re-solving in inflammation). The substance had a therapeutic effect on mice, dramatically reducing the number of pro-inflammatory cytokines and immune cells in both the spinal cord and blood. Continuous lipid administration over time protected neurons from demyelination and reversed neurological disorders caused by this disease.
In the near future, a series of tests and experiments on different animals is planned to prove the safety of marezin therapy.
Article by A.Sánchez-Fernández et al. Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis published in the Journal of Neuroinflammation.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on the materials of the Universitat Autònoma de Barcelona: A new treatment reduces inflammation in multiple sclerosis mice models.