One against many

A molecule has been developed to attack many types of cancer

Svetlana Maslova, Hi-tech+

An antitumor molecule attacking the universal survival mechanism of cancer cells has shown high efficacy in preclinical studies. And without any side effects.

The therapy is aimed at a newly discovered protein complex that includes the mitochondrial fission factor MFF and the potential-dependent anion channel VDAC1. Previous studies have shown that MFF has increased expression during cancer development and interacts with VDAC1, contributing to the survival of malignant cells. The findings of the new study are published on the website of the Vistar Institute (USA).

Article Seo et al. MFF regulation of mitochondrial cell death is a therapeutic target in cancer published in the journal Cancer Research – VM.

The first stage of experiments showed that the destruction of the MFF-VDAC1 complex leads to the death of cancer cells. This helped scientists focus on a new potential target in the fight against cancer. The next step was to create a molecule that could disrupt the interaction of proteins.

The created molecule showed high anti-cancer activity. At the same time, the treatment did not harm healthy cells.

The therapy was tested on prostate, melanoma, lung, breast and glioblastoma cancer cells, including treatment-resistant cells, as well as in preclinical experiments on mouse models.

In all cases, the treatment triggered strong antitumor activity, and in laboratory animals it was well tolerated and did not cause signs of toxicity.

Scientists believe that the drug can be transformed into a new effective antitumor therapy for many types of cancer. The team's research will continue.

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