Protection per second
The spray vaccine has completely stopped the contact transmission of COVID-19
Svetlana Maslova, Hi-tech+
The main advantage of this approach is that the vaccine acts on the entry point of the virus into the body – the mucous membrane of the respiratory tract. The creators of this inhalation vaccine have been developing a platform for it for more than 20 years, but during the pandemic they quickly focused on SARS-CoV-2. Preclinical results of drug testing are very impressive.
Article by Dong An et al. Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 vaccine is published in the journal Science Advances – VM.
An experimental inhaled vaccine was presented by researchers from The University of Georgia and the University of Iowa. "We have been developing this platform for more than twenty years, and since the first days of the pandemic, we have started working on new formulations," the authors said.
The new spray vaccine is administered through the nose.
According to the authors, one dosage of the drug should be enough for a person to form protection for both himself and others.
It is based on an inactivated parainfluenza virus 5, which is used to deliver a spike protein to host cells to trigger an immune response. Previously, scientists have demonstrated that this approach completely protected animals from the MERS coronavirus.
Delivery through the respiratory tract has many advantages over traditional injectable vaccinations. Firstly, the cells of the respiratory tract are the main entry point of the virus into the body and the place of its earliest replication. Secondly, the active presence of the virus in the respiratory tract increases the easy and rapid risk of infection of others. Finally, spray vaccines are much better tolerated by people who, for whatever reason, are afraid or do not tolerate injections.
Experiments on mouse models showed that the vaccine completely protected against COVID-19 deaths, caused the necessary local immune response, including antibodies and cellular immunity.
Testing the vaccine on ferrets completely prevented infection, and also blocked the transmission of the virus from an infected individual to a cell neighbor.
"If the vaccine proves effective in humans, it will block the transmission of COVID-19 and thereby control the pandemic," concluded co–author Paul McCray. The vaccine can be stored for three months in a conventional refrigerator, so this should expand the availability of vaccination in remote regions, he added.
Portal "Eternal youth" http://vechnayamolodost.ru