Implants with growth factor
Scientists have developed a technology for three-dimensional printing of genetically engineered structures for targeted regeneration of bone tissue
RAS Press Center
A group of Russian scientists has developed an original technology for three-dimensional printing of personalized products made of bioactive ceramics and created personalized gene-activated implants. A comprehensive physico-chemical and biochemical analysis of experimental samples of gene-activated materials and personalized implants for engineering and directed regeneration of bone tissues obtained using three-dimensional printing technologies, including preclinical studies on large animals, was carried out. The results of the work are published in the International Journal of Bioprinting (Bozo et al., 3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering).
The work was supported by the RFBR grant 18-29-11081 mk.
Despite the high level of medical development, the problem of treating patients with extended (critical) defects of the bones of the skeleton remains unresolved. The urgency of the problem is emphasized by the prevalence of injuries, oncological pathology, congenital deformities and developmental anomalies, degenerative-dystrophic, inflammatory diseases that directly affect bones or require segmental bone resections during surgical interventions.
Thus, according to the Federal State Statistics Service, 3 million injuries of skeletal bones were registered in Russia in 2015. And according to WHO, in the world, the annual number of victims only as a result of road accidents is 30-50 million people. In the case of extended bone defects, modern reconstructive and reconstructive treatment is based on the use of bone autografts, since osteoplastic materials allowed for use are effective only with small volumes of bone defects, distraction osteogenesis is long and not always applicable, and prosthetics with non-resorbable materials is associated with a high risk of complications and the frequency of unsatisfactory treatment results.
An effective alternative to bone autografts can only be those methods and means that will allow you to quickly and personalizably replenish the lost structure and function of damaged bones, based on the unique features of the skeleton and damage, to carry out partial or even complete bone replacement. Three-dimensional printing technologies (additive technologies) of bioresorbable implants and biotechnological approaches (genetic technologies) offer the greatest prospects in solving this problem.
Taking into account the urgency of the clinical problem, the development of personalized remedies and methods of treatment of patients with skeletal bone pathology is carried out by many research teams, mainly foreign ones.
The key team members have formed a significant scientific and technical reserve in this area, developed an original technology for three-dimensional printing of personalized products from bioactive ceramics and created personalized gene-activated implants. All this is reflected in an article published in the International Journal of Bioprinting.
The article is devoted to creating such a complex structure and conducting a comprehensive physico-chemical and biochemical analysis of experimental samples of gene-activated materials and personalized implants for engineering and directed regeneration of bone tissues obtained using three-dimensional printing technologies, including preclinical studies on large animals.
"The results of this study have high practical and socio-economic significance for high-tech healthcare and fully comply with the tasks set by the President of the Russian Federation within the framework of the program for the development of genetic technologies. The work corresponds to the modern level of interdisciplinary research and development in the field of genetic and cellular engineering of reparative osteogenesis and biomedical materials science," commented Vladimir Sergeevich Komlev, PhD, Corresponding Member of the Russian Academy of Sciences, Director of the A.A. Baykov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences.
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