Another property of rapamycin
It has been established how rapamycin slows down cell growth
In their article published in the journal Cell (Messier et al., A Nutrient-Responsive Pathway that Determines M Phase Timing through Control of B-Cyclin mRNA Stability), the researchers explain how the well-known immunosuppressant rapamycin slows down cell division.
As the author of the study, professor of biochemistry, Dr. Stephen Michnick, explains, dividing cells constantly monitor the presence and quantity of available nutrients, and when they are deficient, they begin to slow down division and growth. A protein called the "rapamycin target" (TOR) helps cells in this tracking, but scientists have not known for a long time exactly how this protein affects the division processes.
In the course of the study, Dr. Michnik and his colleagues found that as soon as cells begin to lack nutrients, TOR synthesizes a small protein signaling molecule. It stops the formation of mRNA synthesizing B-cyclin. This regulator of the cell cycle sends a signal to the cells, forcing them to stop dividing.
Thus, rapamycin is becoming a promising drug for the treatment of certain types of cancer and other proliferative diseases, for example, lymphangioleiomyomatosis.
Portal "Eternal youth" http://vechnayamolodost.ru27.05.2013