Steatohepatitis and neurodegeneration
Scientists have found out how liver diseases lead to Alzheimer's disease
Svetlana Maslova, Hi-tech+
The results of a new study not only confirm the link between non-alcoholic fatty liver disease and the development of neurodegeneration, but also show the mechanisms that lead to this. The work explains the occurrence of symptoms of dementia in people with liver pathology.
Article by Ayan Mondal et al. Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoolic steatohepatitis published in Journal of Neuroinflammation – VM.
Scientists from The University of Southern California presented the results of preclinical studies proving the relationship between non-alcoholic fatty liver disease (NABHT) and neuroinflammation, potentially leading to the development of Alzheimer's and Parkinson's disease. The results of their observations are of great importance for understanding the nature of neurodegeneration, since patients with NAB often develop symptoms similar to neurodegeneration.
Preclinical experiments on mice with the NABJT model have shown the role of one of the adipose tissue hormones lipocalin-2 (Lcn2) in the occurrence of neuroinflammation. High levels of Lcn2 in rodents activated the 24p3R receptor in the brain and induced the release of the HMGB1 protein, presumably from brain cells.
HMGB1 also contributed to the development of oxidative stress, inflammation and the release of pro–inflammatory cytokines - interleukin-6 and interleukin 1 beta, the experiments showed.
Scientists have also found out that an increased level of Lcn2 in case of NAB may be the cause of a violation of the blood-brain barrier of the brain, which separates it from the circulatory system.
It is believed that about 90% of obese people and about 40-70% of people with type 2 diabetes also have a history of NAB. According to a new study, this group of patients also has an increased Lcn2 content in the body.
"Our study will help to develop new therapeutic approaches to combat neuroinflammation in NAB, as well as for other brain pathologies associated with chronic inflammation," concluded study co–author Saurabh Chatterjee.
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