Epigenomics of longevity
Aging and longevity:
epigenome reveals secrets
* – Read more about the processes of epigenetic modification of the genome in the articles: "Development and epigenetics, or the story of the Minotaur" [1], "Epigenetic Clock: how old is your methylome?" [2], "Epigenetics of behavior: how grandma's experience affects your genes" [3].
* – More information about RNA and its associated mechanisms of action on the genome is described in the articles: "About all RNAs in the world, big and small" [4], "How to get rid of RNA in a few minutes" [5], "microRNAs – the further into the forest, the more firewood" [6].
* – You can read about the mobile genetic elements of eukaryotes in the articles: "Secrets of "molecular parasites", or How to travel through the genome" [10], "There is not much diversity: what do mobile elements of the genome do in the brain" [11], "The human genome: a useful book, or a glossy magazine?" [12].
* – ROS and related processes are discussed in more detail in the articles "Active oxygen: Friend or foe, or about the benefits and harms of antioxidants" [19] and "Antioxidants against pyelonephritis" [20].
* – The properties of these proteins are described in the article "Histone rolls, rolls to DNA" [32].
* – This process is perfectly illustrated (literally) in the comic book "Who to be? How the hematopoietic stem cell chooses a profession" [34]. – Ed.
* – The article "Why cells age" figuratively tells about the nature of various, not only epigenetic, age-related changes in cells and possible ways to overcome them [37]. – Ed.
- Biomolecule: "Epigenetic clock:
- how old is your methylome?";Biomolecule: "Epigenetics of behavior:
- how does grandma's experience affect your genes";biomolecule: "About all RNAs in the world, large and small";
- biomolecule: "How to get rid of RNA in a few minutes";
- biomolecule: "microRNA – the further into the forest, the more firewood";
- Callaway E. (2014).
- Epigenomics starts to make its mark. Nature. 508, 22;Vaiserman A.M., Voitenko V.P., Mekhova L.V. (2011).
- Epigenetic epidemiology of age-related diseases. Ontogenesis. 42, 1–21;Hancks D.C. and Kazazian H.H. (2012).
- Active human retrotransposons: variation and disease. Curr. Opin. Genet. Dev. 22, 191–203;Biomolecule: "Secrets of "molecular parasites", or How to travel through the genome";
- biomolecule: "There is never much diversity: what do mobile genome elements in the brain do";
- biomolecule: "Human genome: a useful book, or a glossy magazine?";
- Kucharski R., Maleszka J., Foret S., Maleszka R. (2008).
- Nutritional control of reproductive status in honeybees via DNA methylation. Science. 319, 1827–1830;Lyko F., Foret S., Kucharski R., Wolf S., Falckenhayn C., Maleszka R. (2010).
- The honey bee epigenomes: differential methylation of brain DNA in queens and workers. PLoS Biol. 8, e1000506;Corona M., Velarde R.A., Remolina S., Moran-Lauter A., Wang Y., Hughes K.A., Robinson G.E. (2007).
- Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity. Proc. Natl. Acad. Sci. USA. 104, 7128–7133;Gentilini D., Mari D., Castaldi D., Remondini D., Ogliari G., Ostan R. et al. (2013).
- Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring. Age (Dordr). 35, 1961–1973;Soubry A., Schildkraut J.M., Murtha A., Wang F., Huang Z., Bernal A. et al. (2013).
- Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 11, 29;Cencioni C., Spallotta F., Martelli F., Valente S., Mai A., Zeiher A.M., Gaetano C. (2013).
- Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int. J. Mol. Sci. 14, 17643–17663;Biomolecule: "Active oxygen: friend or foe, or about the benefits and harms of antioxidants";
- biomolecule: "Antioxidants against pyelonephritis";
- Weitzman S.A., Turk P.W., Milkowski D.H., Kozlowski K. (1994).
- Free radical adducts induce alterations in DNA cytosine methylation. Proc. Natl. Acad. Sci. USA. 91, 1261–1264;Grechanina E.Ya., Lesovoy V.N., Myasoedov V.V., Grechanina Yu.B., Gusar V.A. (2010).
- There is a natural connection between the development of certain epigenetic diseases and a violation of DNA methylation due to a deficiency of folate cycle enzymes. Ultrasound perinatal diagnostics. 29, 27–59;Zijno A., Andreoli C., Leopardi P., Marcon F., Rossi S., Caiola S. et al.
- (2003). Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects. Carcinogenesis. 24, 1097–1103;Kim C.S., Kim Y.R., Naqvi A., Kumar S., Hoffman T.A., Jung S.B. et al. (2011).
- Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc. Cardiovasc. Res. 92, 466–475;Galimov E.R. (2010).
- The role of p66shc in oxidative stress and apoptosis. Acta Naturae. 4, 49–56;Kim Y.R., Kim C.S., Naqvi A., Kumar A., Kumar S., Hoffman T.A., Irani K. (2012).
- Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction. Am. J. Physiol. Heart Circ. Physiol. 303, 189–196;Pani G. (2010).
- P66SHC and ageing: ROS and TOR? Aging (Albany NY). 2, 514–518;Blagosklonny M.V. (2013).
- MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer. Cell Cycle. 12, 1842–1847;Ranieri S.C., Fusco S., Panieri E., Labate V., Mele M., Tesor V., Ferrara A.M. et al. (2010).
- Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance. Proc. Natl. Acad. Sci. USA. 107, 13420–13428;Tollefsbol T. (2014).
- Dietary epigenetics in cancer and aging. Cancer Treat. Res. 159, 10;O’Sullivan R.J., Kubicek S., Schreiber S.L., Karlseder J. (2010).
- Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat. Struct. Mol. Biol. 17, 1218–1225;biomolecule: "Rolling, rolling to DNA histone";
- Galitsky V.A. (2009).
- The epigenetic nature of aging. Cytology. 5, 388–397;Biomolecule: "Who to be?
- How a hematopoietic stem cell chooses a profession";Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L. et al.
- (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA. 102, 10604–10609;Wang S.C., Oelze B., Schumacher A. (2008).
- Age-specific epigenetic drift in late-onset Alzheimer’s disease. PLoS ONE. 3, e2698;biomolecule: "Why cells age";
- Vanyushin B.F. (2013).
- Epigenetics today and tomorrow. Vavilov Journal of Genetics and Breeding. 17, 805–832.Portal "Eternal youth" http://vechnayamolodost.ru