Dangerous mutation
The cause of a particularly dangerous cancer in men is named
Scientists at Cardiff University (UK) have discovered a mutation that contributes to the development of an aggressive form of malignant tumors called castration-resistant prostate cancer. This is reported in the press release of New genetic link for prostate cancer.
It is known that patients with metastatic prostate cancer initially respond well to hormone therapy, in which the concentration of male sex hormones decreases. At the same time, almost all patients eventually – after about 2-3 years – develop a castration-resistant tumor that cannot be cured, despite low testosterone levels.
Researchers have found that a mutation affecting the PIK3CA gene in prostate cells contributes to the development of an aggressive form of neoplasm. PIK3CA encodes a protein that is a subunit of the enzyme phosphoinositide-3-kinase (PI3K) involved in the process of cell growth, division and their escape from apoptosis (programmed cell death). Another PTEN gene is responsible for blocking the activity of PI3K, and mutations in it also cause the development of tumors.
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