Microflora as a marker of intestinal cancer
The development of colorectal cancer has been linked to bacteria
Copper news based on the materials of Science Daily: New colon cancer culprit found in gut microbiomeThe staff of the University of Minnesota reported that infection with some bacteria may be associated with the progression of colorectal cancer.
According to the data presented in the journal Genome Medicine (Burns et al., Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment, publicly available – VM), a change in the intestinal microflora is an important diagnostic sign that can help a doctor predict the development of the disease.
Scientists led by Michael Burns have discovered two pathogenic strains, the presence of which in the intestinal microflora is a marker of the disease. They turned out to be gram-negative representatives of the genus Providencia. "It's amazing that the results were so obvious. We were able to pinpoint two pathogenic bacterial strains," Burns said.
This was the first study in which scientists analyzed the pathogenic potential of bacterial genes present in the "tumor microenvironment" – the biological environment that surrounds blood vessels, as well as body cells. "The presence of these bacteria has obvious consequences for patients suffering from cancer. We have discovered a kind of marker that can help doctors identify this type of malignant neoplasm," the authors of the study added.
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26.06.2015