"The stroke gene"

Stroke risk linked to gene mutation

Copper newsBritish and German scientists have discovered a mutation of one of the genes, the presence of which doubles the risk of the most common form of stroke, writes The Independent (New genetic discovery could boost treatment for stroke patients).

The researchers conducted a genome-wide association analysis in 3,548 Europeans who had a stroke and 5,972 healthy people for control. This analysis showed a clear association of ischemic stroke due to damage to a large artery with a mutant variant of the HDAC9 gene. The data obtained were reproduced in more than 6,000 people after a stroke and almost 35 thousand who did not tolerate this disease.

This gene encodes the enzyme histone deacetylase type 9, which is involved in the regulation of gene activity and protein synthesis by changing the configuration of the corresponding DNA sites. It was previously shown that histone deacetylase determines how tissues respond to a lack of blood supply (ischemia).

According to the researchers, about 10 percent of HDAC9 genes are affected by the identified mutation. If a person inherits mutant variants of the gene from both parents, the risk of ischemic stroke due to damage to a large artery is doubled compared to carriers of normal variants of the gene.

According to researcher Peter Donnelly from the University of Oxford, the results obtained can contribute to the development of personalized medicine.

The research report is published in the journal Nature (Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke – VM).

Portal "Eternal youth" http://vechnayamolodost.ru08.02.2012