With HIV and hepatitis C, one vaccine will help
Smallpox turned out to be a cure for hepatitis and HIV
A group of immunologists led by Lucy Dorrell from Oxford University has developed a combined vaccine against hepatitis C virus (HCV) and human immunodeficiency virus (HIV). The results of the study are presented at The International Liver Congress in Barcelona. The press release is published on the EurekAlert website! (Combined HIV and hepatitis C virus vaccination a possibility).
Scientists have applied an approach that allows to increase the effectiveness of the use of vaccines compared to individual vaccinations. First, doctors prepare human immunity by injecting adenoviral vectors containing RNA fragments of both viruses into the body. These fragments encode antigens that induce an immune response. After that, repeated vaccination is carried out using the MVA vector (modified cowpox virus, Modified Vaccinia Ankara – VM), which also contains fragments of HIV and HCV.
The first phase of clinical trials involved 32 healthy volunteers, who were divided into three groups. The first group received the hepatitis C vaccine and was re-vaccinated after eight weeks. The second group was vaccinated against HIV according to the same scheme. The third group received a combined vaccine. The researchers then measured the number of specific T cells in the blood samples.
The results of the study showed that after revaccination with the MVA vector, the number of lymphocytes specific to hepatitis and HIV virus antigens increased from several hundred to thousands of units per million lymphocytes. At the same time, all vaccines were well tolerated.
Earlier, geneticists from Temple University demonstrated the possibility of using the CRISPR/Cas9 system to purify human DNA from HIV genes embedded in it.
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15.04.2016