Stroke treatment will become more effective
A new stroke treatment strategy has shown promising results in mice
Svetlana Maslova, Hi-tech+
Scientists have developed a new simple method of treating the effects of stroke. It consists in the introduction of special protective proteins into the blood. If such infusions are carried out at the earliest stage, for example, on the way to the hospital in an ambulance, then we can hope for a significant reduction in the risks of complications.
Currently, only one drug, a tissue plasminogen activator, is available to patients with ischemic stroke to reduce the risk of thrombosis. It must be administered in the first hours after a stroke, but even with timely administration, the effect is observed in only a third of patients. The main complications of stroke include movement disorders and paralysis, speech disorders, difficulty swallowing and other problems.
Scientists from The University of Oslo offers a new method of stroke treatment — the introduction of the protective protein FSAP into the blood, writes New Atlas. It is known from clinical observations that the level of FSAP increases in the bloodstream of patients after a stroke. In addition, people with a mutation in the FSAP gene that reduces the level of protein production are often at increased risk of stroke.
Now the team has demonstrated that FSAP really has protective properties.
Article by Kim et al. Factor VII activating protease (FSAP) inhibits the outcome of ischemic stroke in mouse models published in the FASEB – VM journal.
In mice, the researchers first removed the FSAP gene, which led to serious complications of stroke. They then showed that introducing FSAP into the bloodstream significantly improves the condition of mice with ischemic stroke.
Finally, FSAP was applied together with a tissue plasminogen activator, which further enhanced the positive effect. Without FSAP, standard therapy showed less effective results.
Experimental treatment should be introduced at the earliest stage to prevent severe brain damage, scientists specify. Now they plan to evaluate the safety and potential of therapy for humans.
Portal "Eternal youth" http://vechnayamolodost.ru