Thrombosis-on-a-chip
Blood cells on a chip will allow you to learn more about thrombosis and their treatment
ivansychev, Geektimes based on The Verge: Blood clots on a chip may mean better life-saving drugsIt takes an average of five billion dollars to bring medicines to the market in the United States, 60% of which is for research.
The use of models of human organs will reduce costs and reduce the cost of development, and the absence of the need to use experimental animals will make the testing of drugs for humans more effective.
Here and below are the drawings from the site emulatebio.com – VM.
The "organs-on-chips" technology was created at Harvard. Researchers reproduce the microarchitecture and functions of living organs, in the list of successful experiments — the heart, lungs, intestines. Each chip consists of a transparent polymer, has the size of a flash drive and contains hollow microchannels in which living human cells are located.
In March 2015, the University of California at Berkeley created a heart on a chip: living cells pulsate and respond to drugs. Scientists "packed" cells with a microchip, the cells formed tissue and a day later began to pulse at a frequency of 55 to 80 beats per minute — this is the normal pulse of an average adult. When the "heart" was affected by isoproterenol, the pulsation increased.
Emulate, Inc. develops the Harvard concept. The next step is "thrombosis—on-a-chip": models simulate the factors leading to the formation of blood clots. Clots can stop bleeding from a small wound, but rapid blood clotting can block the flow to organs — the brain, heart and lungs.
Deep vein thrombosis is characterized by the formation of blood clots in deep veins, most often in the lower extremities. The disease occurs in 10-20% of the population and, if left untreated, causes up to 15% of deaths from pulmonary embolism. The study of blood behavior will help pharmaceutical companies come up with more effective ways to treat such diseases. The chips will allow testing new treatments without harming living beings.
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24.06.2015