12 September 2022

Allergen-free herd

Kuban scientists have proposed a method for detecting allergens in cow's milk

Press Center of the Ministry of Education and Science

Will the cow give milk that won't cause allergies? — The answer to this question within one hour is given by the method of genetic analysis of milk developed by Kuban scientists. A simple and cheap test will allow livestock breeders to form a herd of "hypoallergenic" cows and get more safe easily digestible milk. And consumers should avoid allergies.

The cause of allergies

From the point of view of the formulation, milk is an emulsion of water, fats, milk sugar — lactose, proteins, as well as trace elements. Among the proteins contains casein — a complex protein. It comes in two types: A1 and A2. Milk, which contains "good" A2-casein, does not cause allergies.

Milk of the second type — "A1-milk" — contains "bad" casein. When it is cleaved, a dangerous substance is formed — the opioid peptide (chain of amino acids) BCM7. This peptide increases the production of histamine, a substance with which a person begins an allergic reaction. In addition, the BCM7 peptide can negatively affect well-being and health, can provoke the development of childhood autism, lead to a delay in psychomotor development, muscle tone disorders and become a pathogenic factor in a number of diseases.

How the new method of genetic analysis of milk works

The development of scientists of the Kuban State Agrarian University (KubGAU) allows using a genetic test to determine whether "good" or "bad" casein will be contained in cow's milk. It is enough for an animal to conduct just one test, even at a very early age, after which animal breeders can form an "A2 herd" and receive high-quality hypoallergenic dairy products.

"To obtain accurate results, a small amount of genetic material is enough to show that the milk of this cow will contain the dangerous A1-beta-casein gene. A complete analysis of the sample takes only 20-60 minutes," comments Valeria Knyazeva, a researcher at KubGAU, author of the development of an innovative method for testing beta-casein.

"The advantages of the method are also less stringent requirements for laboratory sterility, automatic registration and interpretation of the results obtained. Our development also makes it possible to reduce several very time—consuming stages of traditional research at once and helps to avoid classic errors and false positive test results," added Valeria Knyazeva's supervisor, Vice-Rector for Scientific Work of the Kuban State Agrarian University, Doctor of Biological Sciences, Academician of the Russian Academy of Sciences Andrey Koshchaev.

The method of genetic analysis of milk was developed by scientists of the Kuban State Agrarian University (KubGAU) as part of the implementation of the strategic project "Genetics and breeding in animal husbandry and crop production" under the program of the Ministry of Education and Science of Russia "Priority 2030" (national project "Science and Universities").

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