Not only Helicobacter
Scientists have found the genes responsible for intestinal ulcers
The connection between the genes of proteolytic enzymes and duodenal ulcer in the population of Central Russia was the first in the world to be discovered and described by scientists of the Belgorod State National Research University (NRU "BelSU") together with colleagues from Saudi Arabia. The authors of the work believe that its results can already be used in practical gastroenterology and teaching medicine. The article was published in the Journal of King Saud University – Science (Minyaylo et al., Polymorphisms of the matrix metalloproteinase 9 gene are associated with duodenal ulcer in a Caucasian population of Central Russia).
Duodenal ulcer is a fairly common disease that affects up to 10 percent of the world's population, according to the article. Infection with Helicobacter pylori caused by Helicobacter pylori bacteria has a particularly strong effect on its development. Excessive alcohol and tobacco consumption, improper nutrition, abuse of medications (for example, aspirin) and others can also lead to illness.
All these negative factors simultaneously provoke increased production of hydrochloric acid in the stomach and violation of the mucous barrier on the walls of the intestinal tract. Constant inflammation of damaged areas of the mucosa in an acidic environment leads to the formation of ulcers.
Medical practice shows that the process in some patients progresses rapidly and deeply affects the intestines, while in other patients the disease does not develop even under extremely unfavorable conditions. According to scientists of the Belgorod State National Research University (NRU "BelSU"), they, together with colleagues from Al-Faisal University, managed to show that genetic factors play a decisive role in the development of the disease.
"For the first time in the world, we have found an association of polymorphic variants of the matrix metalloproteinase-9 gene with the development of duodenal ulcer in H.pylori infected individuals. Moreover, we have identified specific genetic markers associated with an increased risk of developing the disease in the population of Central Russia," said Mikhail Churnosov, Head of the Department of Biomedical Disciplines at the National Research University "BelSU".
According to the authors of the work, the data they have obtained can already be used in practical gastroenterology (to identify a risk group among a healthy population), as well as in teaching medical genetics and gastroenterology.
"Previously, there were only three attempts of genetic research of this kind in the world, as a result of which ambiguous results were obtained. The scientific facts established in this study significantly expand the ideas available in world science about the role of matrix metalloproteinase genes in the formation of duodenal ulcer," Churnosov emphasized.
The published results indicate gene alleles associated with an increased risk of duodenal ulcer and alleles that increase the risk of developing the disease in people infected with helicobacteriosis.
Portal "Eternal youth" http://vechnayamolodost.ru