Training gene
The discovery of the muscle strength gene will allow you to build muscles without training
Stepan Ikaev, Hi-tech+
A group of scientists from Copenhagen and Melbourne Universities have discovered a gene responsible for building muscle mass. According to the results of the study, hereditary factor C18ORF25 is a key gene that is activated during exercise. The discovery will form the basis of many important projects in the field of healthcare — from the creation of drugs for the development of physical strength without training to new methods to combat muscle atrophy and other diseases, according to a press release from Researchers discover gene that promotes muscle strength during exercise.
The fact that regular sports and physical exercises strengthen human health is a well—known fact. But it is much more difficult to determine the specific mechanisms that affect muscle mass building, the scientists said. For the new study, Danish and Australian experts studied the molecular reactions in muscles before, during and after various exercises.
"To determine how genes and proteins are activated during and after various exercises, we analyzed human skeletal muscles during cross—training in endurance, sprint and resistance exercises," said Dr. Benjamin Parker, lead author of the study.
Using the data obtained, the team analyzed how the reactions in the muscles changed after different types of exercises in each volunteer, as well as how consistent the changes were in different people. As a result, scientists have identified a previously uncharacterized gene called C18ORF25, which was activated most often in all subjects.
Next, the scientists brought out several models of laboratory mice — some were deprived of C18ORF25, others, on the contrary, the presence of this gene was intensified. The first group developed more slowly due to weak muscles and low physical activity, while the second showed outstanding results. The higher the activity of the C18ORF25 gene, the stronger the muscles of the animals became.
"Identifying this gene can affect how we manage healthy aging, muscular atrophy diseases, sports science, and even animal husbandry and meat production. This is due to the fact that optimal muscle function is one of the best indicators of overall health," added Dr. Parker.
According to Parker, exercise can prevent many diseases, including diabetes, cardiovascular diseases and many types of cancer. If scientists can find an effective application of the new gene, all the mentioned diseases will pose less danger to humans.
Article by Blazev et al. The phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function is published in the journal Cell Metabolism – VM.
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