Technology and Microfacturing Center
FMBA Press Center
On September 29, as part of the Year of Science and Technology, a solemn opening ceremony was held for the first Technology and Microfacturing Center in Russia, which was created as a result of the implementation of the Federal Target Program "Pharma 2020" on the basis of the Federal Scientific and Clinical Center of Physico-Chemical Medicine of the Federal Medical and Biological Agency.
The opening ceremony was attended by Veronika Skvortsova, Head of the FMBA of Russia, Alexey Medvedev, Deputy Minister of Science and Higher Education of the Russian Federation, Vasily Shpak, Deputy Minister of Industry and Trade of the Russian Federation, Ilya Kurochkin, Director of the N.M. Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, member of the Council of the Chamber of Commerce and Industry of the Russian Federation, member of the Public Council under the Ministry of Health Valery Sergienko, Head of the Federal Scientific and Clinical Center of Physico-Chemical Medicine of the FMBA of Russia Maria Lagarkova and others. The opening ceremony was held by the presenter of the TV channel "Russia 1" Ernest Mackevicius.
Dmitry Chernyshenko, Deputy Prime Minister of the Russian Federation, Co-Chairman of the Organizing Committee of the Year of Science and Technology, greeted the guests of the opening ceremony of the Center: "The thematic month of the Year of Science and Technology, dedicated to genetics and quality of life, was marked by several important events in the development of scientific infrastructure. In September, the Pioneer-M research vessel was launched, and the construction of two research vessels was launched. The opening of the first Technology and Microfacturing Center in Russia on the basis of the Federal Scientific and Clinical Center of Physico-Chemical Medicine of the Federal Medical and Biological Agency will continue a number of significant scientific events and create conditions for the implementation of new ideas of Russian scientists, designers and engineers for the development of biomedicine. The Center for Technologies and Microfacturing will allow representatives of different specializations to cooperate and jointly conduct both scientific and applied research, and develop, design work, create prototypes and even experimental batches of medical devices and diagnostic systems based on microfluidic and nanotechnologies."
Veronika Skvortsova, Head of the FMBA of Russia, emphasized the uniqueness of the Center for Technologies and Microfacturing: "The Center is a platform where not only biologists, doctors and representatives of fundamental medicine, but also designers and engineers work in one team. This collective work allows us to approach the problem of a complete innovation chain and accelerate the development of new diagnostic methods and unique innovative devices for in vitro diagnostics. The Center uses the most modern technologies, such as plasmonics, photonics, microfluidic technologies, nanotechnology and their joint coupling, which is especially important. The use of such important techniques and methods as microlithography, laser micro-welding, as well as a combination of fundamental and high-tech methods allow you to create unique products. These are, first of all, medical microelectronic products with very low dimensionality, various nanostructures made of different materials, such as silicon, quartz, plastic, various metal variants, a whole range of various sensors for the diagnosis of diseases, microfluidic chips, including for the diagnosis of viral infections and SARS-CoV-2, various optical, optomechanical and electronic analyzers, which form the basis of the most modern diagnostic devices."
Veronika Skvortsova stressed that the structure of the Federal Scientific and Clinical Center of Physico-Chemical Medicine also includes a clinic: "The proximity and constant communication of scientists and developers with practitioners allows us to quickly validate those tests and diagnostic systems that are produced here, to test them in patients of different profiles," said the head of the FMBA of Russia Veronika Skvortsova.
The head of the Agency also noted that all the premises of the Center are designed and equipped taking into account modern world requirements. The center is equipped with an innovative production complex for the creation of diagnostic systems and medical devices based on microfluidic chips. They are devices capable of creating conditions for calculating the characteristics of a liquid that enters special channels in a chip with a size of hundreds or even tens of microns. Microfluidic systems are used in advanced areas of medical science and allow scientists to effectively crystallize proteins used in medical preparations. Protein crystallization is the final stage of its purification from impurities and unwanted molecules that can join it in its liquid state. Moreover, thanks to microfluidic chips, researchers can study new properties and effects of liquid substances that are impossible in traditional devices for conducting experiments. In particular, the use of such chips to create compact devices for medical blood analysis is considered promising.
"Creating complex nano-sized devices like microfluidic chips requires a special environment and high-precision equipment. The Center for Technologies and Microfactories has created all conditions for the sterility of premises, which practically exclude the presence of foreign particles and microorganisms in the air and comply with the class of requirements for the cleanliness of premises ISO-5/ISO-7. The Center also has equipment for microlithography and laser micro–welding: with their help, it will be possible to create complexes of various purposes of very small sizes, for example, microelectronic devices for specific medical purposes," said Veronika Skvortsova, head of the FMBA of Russia. – Innovative devices for laser micro-welding and the creation of microfluidic systems will provide scientists with the opportunity to create domestic high-tech medical devices capable of competing with international analogues. It is worth noting that conducting research in the field of DNA decoding and point manipulations with individual genes require very high-precision equipment, as well as significant computing power. With the help of the technical base of the Microfacturing Center, Russian scientists will have access to domestic innovative equipment."
Deputy Minister of Science and Higher Education of the Russian Federation Alexey Medvedev also welcomed all the guests of the solemn event and congratulated the head of the FMBA of Russia Veronika Skvortsova and the Agency staff on the opening: "In the Year of Science and Technology, which was announced by the President of the Russian Federation, we witnessed the opening of such a wonderful Center. Indeed, the Year of Science is divided into a number of thematic months, September is the month of genetics and quality of life. I am very glad that the opening of this Center was such a bright event in its finale. Each center of the FMBA of Russia is a fusion of great science, high technology and a high–quality clinic. This is an amazing "gluing" of technological solutions that are based on research and development, which are almost immediately applied in clinical medicine – this is a feature of those centers that are being created and have already been created within the framework of the Federal Medical and Biological Agency."
Vasily Shpak, Deputy Minister of Industry and Trade of the Russian Federation, noted the unique capabilities of the Center for Technology and Microfabrication, wishing success to the Center's staff: "We were really looking forward to the opening of this Center. Although it is a Center of technology and microfacturing, but in fact it will have a macro effect. This will allow us to open a completely new page in approaches to saving and multiplying the health of our citizens, will give new opportunities to telemedicine, will allow not only to find out the symptoms and treat diseases, but also to build individual health tracks of our citizens based on big-data and the use of artificial intelligence. Sensorics, which will primarily be created in this Center, will give completely new unique opportunities for our medical equipment and the medical industry. Good luck and success to the staff of the Center, we really want to start working together as soon as possible."
Vasily Shpak also drew special attention to the close cooperation of the Ministry of Industry and Trade of the Russian Federation with the FMBA of Russia: "We have been cooperating very closely with the Federal Biomedical Agency for quite a long time. We have a corresponding joint order signed by Veronika Igorevna and our Minister, within the framework of which we carry out our joint activities. We have found a strong industry partner in the face of the FMBA of Russia, in the face of the Center being created. This will allow us to give a completely new quality to the medical equipment that we produce, and to put on the market a new generation of devices that we could only dream of before. We plan to strengthen and expand our cooperation."
The Center for Technologies and Microfacturing of the Federal Scientific and Clinical Center of Physico-Chemical Medicine of the Federal Medical and Biological Agency was established as a result of the implementation of the Federal Target Program "Pharma 2020".
As part of the pilot operation, the staff of the Center developed a device for individual rapid testing for the presence of coronavirus infection, developed at the FNCC FHM FMBA of Russia. The Izascrin-8 portable analyzer allows detecting DNA/RNA pathogens of infectious diseases, including the new coronavirus infection of 2019, in biological material (a smear from the throat) within 25-30 minutes. The time of a complete analysis to search for the RNA of the COVID-19 pathogen is less than 30 minutes, while the time of extraction of RNA from the sample is about 10 minutes, the process of reverse transcription and amplification with optical registration of the process in real time is 17.5 minutes. The device is designed for simultaneous production of two samples with controls to obtain a validated analysis result. "Izascreen-8" is designed for mobile use in laboratories and testing points, ambulance crews, sports medicine doctors.
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