02 October 2020

Signs of aging

Scientists have identified key regulators of aging in mice and humans

Georgy Golovanov, XX2 century

The aging process affects all cells of the body, and understanding how it works will allow you to "age better, without diseases," as the researchers say. Swiss scientists from the Federal Polytechnic School of Lausanne have measured the molecular trace that aging leaves on various tissues of the body of mice and humans. Using these data, they identified the most likely regulators of this complex process.

In the article Sleiman et al. The Gene-Regulatory Footprint of Aging Highlights Preserved Central Regulators, published in the journal Cell Reports, the authors asked a simple question: how do the tissues of aging mice differ from the tissues of adult mice? To answer, they used technology to measure gene expression and identify epigenetic differences. The researchers not only measured different levels of information, but also did it for three types of tissues: liver, heart and muscles.


The collected data allowed them to identify the "trace" of aging, which can serve as a field for research. However, despite the fact that they were able to identify many symptoms of aging, the tissues behaved differently, according to a press release Understanding the effect of aging on the genome.

After conducting multiple bioinformatics analysis, the scientists identified certain genes and proteins that control the complex aging process. By including human data in the analysis, they showed that much of what was discovered in the mouse genome is also applicable to human aging.

In addition, scientists have used human genetic data to show that a number of properties can explain why some people live longer than others.

"Our ultimate goal is not to stop aging, but to age better, without diseases, and for this we need to describe this system," said Johan Auwerks, one of the researchers. – This is a perfect example of interspecific integration, starting with laboratory mice and ending with population data, which brings us closer to understanding one of the most complex processes in biology."

Recently , biologists from the USA have discovered the key mechanisms of aging. Having identified two separate pathways that cells pass through during age-related changes, they have developed a new way of genetic programming of these processes, which will increase life expectancy.

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