Electroceutics against arthritis

The final tests of the implant for the treatment of rheumatoid arthritis have begun

Svetlana Maslova, Hi-tech+

The tablet-sized implant sends electrical signals to the vagus nerve and thereby reduces inflammation. The new strategy is still being studied as part of the final third phase of clinical trials of rheumatoid arthritis, but scientists plan to apply the approach to other autoimmune diseases.

Autoimmune diseases are accompanied by chronic inflammation in the body, although some of them can currently be controlled with anti-inflammatory drugs. Meanwhile, the drugs are not suitable for everyone and against the background of long-term use, the risks of side effects increase. Scientists from the USA have developed a technology that can stimulate the vagus nerve and reduce inflammation. As part of the final phase of the trials, it will be tested on 250 volunteers with rheumatoid arthritis, according to a press release from the University of Washington Can an electroceutical treat rheumatoid arthritis?

The mini-implant is inserted into the body by a small incision. It is charged wirelessly once a week using a small device that is attached to the neck for one hour.

The implant sends electrical signals to the vagus nerve, which can act as a brake on the immune system, telling the spleen to release fewer inflammatory molecules, the authors explain. Previous studies have shown that this approach improves the signs and symptoms of rheumatoid arthritis.

The observation will last for three years, but the period of active stimulation will be only 12 weeks. If the approach proves effective again in comparison with the placebo group, the scientists plan to test the technology for a number of other autoimmune diseases.

"We strive to ensure that patients can forget about taking pills daily and the side effects of therapy," the authors said.

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