Fat leak
About 250 people are diagnosed with Alzheimer's disease every day in Australia, and about 500,000 Australians live with this disease in total. Without significant medical breakthroughs, it is estimated that by 2058 the number of Australians living with dementia will exceed one million.
It is known that in Alzheimer's disease there is a progressive accumulation of conglomerates of the toxic beta-amyloid protein in brain tissue, but it is still unclear where it comes from and why it is deposited in the brain. Researchers from Curtin University in Australia have identified the probable cause of Alzheimer's disease – the most common form of dementia worldwide. They showed that toxic deposits of beta-amyloid most likely enter the brain with lipoproteins contained in the blood.
Previous studies have shown that beta-amyloid is formed outside the brain with the participation of lipoproteins. The research team traced its path from the blood to the brain using genetically engineered mouse models in which beta-amyloid is synthesized by lipoproteins in the liver. As expected, mice producing lipoprotein-amyloid in the liver suffered from inflammation in the brain, accelerated death of nerve cells and memory disorders.
Thus, there is a potential opportunity to reduce the risk of developing and stop the progression of Alzheimer's disease if the excess of beta-amyloid in the blood is eliminated with the help of a special diet or drugs that block lipoprotein-amyloid.
Currently, the group is conducting a clinical study of probucol in Alzheimer's disease, which is based on accumulated data that this drug reduces the production of lipoprotein amyloid and preserves cognitive functions in mice.
Article V.Lam et al. Synthesis of human amyloid restricted to liver results in an Alzheimer's disease–like neurodegenerative phenotype published in the journal PLOS Biology.
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on materials from Curtin University: New Curtin research identifies likely cause of Alzheimer's disease.