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Five courses of antibiotics increase the risk of intestinal inflammation by 236%

Svetlana Maslova, Hi-tech+

One or more courses of antibiotics for five years significantly increased the likelihood of developing Crohn's disease and ulcerative colitis, scientists found. Their results again indicate the need to take antibacterial drugs exclusively under the supervision of a specialist and strictly according to indications.

In certain conditions, refusal of antibiotics can lead to death, but frequent use of drugs can provoke serious complications. In the new work, scientists analyzed data from people over 60 who are at increased risk. For them, environmental factors such as antibiotics dominate genetics, the authors explain.

They studied the history of volunteers in the period from 2000 to 2018 and the number of courses of antibiotics that were prescribed. Observations showed that the risks of ulcerative colitis and Crohn's disease increased with each additional course of antibiotics. After one, the risks were 25% higher, after two — 55%, three — 67%, four — 96% (almost twice), writes EurekAlert.

Five or more courses within five years increased the likelihood of inflammatory bowel diseases by 236% (almost 3.5 times).

The risks were highest if the drugs were prescribed one to two years before the diagnosis. The relationship was confirmed for all types of antibiotics, except nitrofurantoin, which is indicated for the treatment of urinary tract infections.

The most serious risks were for antibiotics prescribed for the treatment of gastrointestinal tract infections.

In addition to preventing resistance, the reasonable administration of antibacterial drugs has important consequences for the prevention of inflammatory bowel diseases, according to the findings of the work.

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