17 June 2024

Pantoprazole protected intensive care patients from bleeding from stress ulcers

A clinical trial conducted in eight countries showed that pantoprazole reduced the risk of death from upper gastrointestinal bleeding in intensive care patients with stress gastric ulcers. Thus, death due to such bleeding occurred in one per cent of patients receiving pantoprazole and 3.5 per cent of patients receiving placebo (hazard ratio 0.30, p < 0.001). The results of the study are published in The New England Journal of Medicine.

Critical care patients are at risk for stress ulcers of the stomach, which can be complicated by bleeding. Proton pump inhibitors are used to prevent these ulcers, but in recent studies, pantoprazole increased the risk of death in a subgroup of patients with the most severe course of the disease. In the present study, conducted by a team of scientists led by Deborah Cook of McMaster University, 90-day mortality did not differ between the two groups (29.1 per cent deaths in the pantoprazole group and 30.9 per cent in the control group, p = 0.25). A total of 4,821 critically ill patients on invasive ventilator support participated in the trial.

Found a typo? Select it and press ctrl + enter Print version