Mouse-mouse, here's a tooth for you!
The Japanese grew teeth from mouse stem cellsCNewsR&D based on the materials of JCN Newswire:
Research Group Headed by Professor Takashi Tsuji
Demonstrates Regenerating "Fully Functional Bioengineered Mature Tooth Unit"Researchers at the University of Tokyo managed to grow full-fledged teeth with dental bones and connective fibers from mouse stem cells and successfully transplant them into the jaws of animals.
To do this, they isolated from molars (large molars) mice received two types of stem cells and placed them in molds that were supposed to ensure the formation of the desired shape of artificial teeth. The structures formed after 60 days of cultivation were implanted into the lower jaws of month-old mice. (The fact that the blanks were cultured not in an airless space, but under a kidney capsule, and other interesting details about the manufacture of artificial teeth can be read in the article Masamitsu Oshima et al., Functional Tooth Regeneration Using a Bioengineered Tooth Unit as a Mature Organ Replacement Regenerative Therapy, published in PLoS ONE – VM.)
This is what a tooth from stem cells looks like at different stages of cultivation
Within 40 days, the implants successfully fused with the surrounding jaw bones. The analysis of the implant tissues revealed even the presence of nerve fibers, which indicated the complete integration of the teeth into the surrounding tissues. At the same time, the transplanted teeth did not cause difficulties when eating and chewing.
Photos of the jaw (top) and microtomography results (bottom),
demonstrating the closure of natural teeth (left),
and jaws, in one of which a bioengineered tooth is implanted (right)
The scale ruler in both figures is 0.5 mm
Scientists believe that their achievement is an important step towards the development of methods for growing teeth from human cells. They note that dental stem cells are an ideal material for this purpose, as they are able to differentiate into cells of enamel, dentin, dental bones and connective fibers. Moreover, these cells can be isolated from the so-called wisdom teeth without compromising the condition of the human oral cavity.
Portal "Eternal youth" http://vechnayamolodost.ru15.07.2011