Once again about the dangers of fructose
Research has shown that fructose increases inflammatory bowel diseases
Anna Yudina, "Scientific Russia"
Diet remains an important part of the prevention and treatment of diseases, and a new study shows that fructose consumption can worsen intestinal inflammation characteristic of intestinal diseases (IBD), according to a press release from Stony Brook University Fructose May Worsen Inflammatory Bowel Disease.
The study, led by David Montrose, PhD, from the Renaissance School of Medicine at Stony Brook University, is currently published online in the journal Cellular and Molecular Gastroenterology and Hepatology.
The frequency of IBD is growing all over the world. According to the Centers for Disease Control and Prevention (CDC), approximately three million Americans are diagnosed with IBD each year, which is one million more than in the late 1990s. Adherence to a Western diet that includes fructose is associated with an increase in obesity and diabetes, and inflammatory bowel diseases can be an additional disease aggravated by the use of fructose.
"The increase in the incidence of IBD corresponds to a higher level of fructose consumption in the United States and other countries," says Montrose, associate professor of pathology and researcher at the Stony Brook University Cancer Center. – Our results indicate a direct link between dietary fructose and IBD and confirm the concept that high fructose intake can worsen the course of the disease in people with IBD. This is important because it can give recommendations on the choice of diet for patients with IBD, which is currently lacking."
Montrose and colleagues from Weill Cornell Medicine tested three mouse models of IBD. They were fed large amounts of fructose, which aggravated inflammation of the colon, and also had a noticeable effect on intestinal bacteria, including changes in their type, metabolism and localization in the colon. Additional mechanistic work has demonstrated that the microbiota is causally related to the detrimental effects of a high-fructose diet.
The article concludes that "excessive consumption of fructose with food had a procolytic effect, which can be explained by changes in the composition, distribution and metabolic function of the resident intestinal microbiota."
Montrose says several next steps are planned to expand on these results. This includes developing measures to prevent the pro-inflammatory effects of dietary fructose, as well as evaluating whether this diet increases the carcinogenesis associated with colitis. The second point is especially important, since patients with IBD are at increased risk of developing colon cancer due to chronic intestinal inflammation throughout their lives.
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