Exosomes against wrinkles

Scientists rejuvenated the skin of mice without injections

Svetlana Maslova, Hi-tech+

Aging of the skin makes people turn to cosmetic procedures to cope with wrinkles and increase the elasticity of the skin. Modern injection methods retain the rejuvenating effect for only a few months, so such approaches cannot be called effective. American scientists have successfully tested a new approach for the treatment of skin aging – exosomal therapy.

Article by Hu et al. Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging is published in the journal ACS Nano.

Exosomes are extracellular vesicles, or vesicles, that are secreted by various cells for communication. In their work, the scientists used exosomes from human dermal fibroblasts and developed a completely non-invasive procedure for smoothing wrinkles.

Preliminary experiments on cell culture have shown that the treatment of human skin cells with exosomes increases the amount of collagen and causes other rejuvenating changes.

The team then conducted experiments with mice that had previously been exposed to ultraviolet light, which accelerates skin aging, for eight weeks.

The main know-how of the new technology is a needle–free injector, which uses a jet of air to implant exosomes under the skin.

Three weeks after treatment, the rodents had thinner and more superficial wrinkles, the skin became thicker and firmer. In addition, the skin had less inflammation, and collagen synthesis, which usually decreases with age, increased. In the control group, scientists used standard renitoic acid to reduce the symptoms of skin aging, but there were no such impressive effects.

The therapy has the potential to treat skin aging in humans, the authors are sure. The research will continue.

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