Mice protected from Alzheimer's
Alzheimer's vaccine has been tested on animals
A potential vaccine for the prevention of Alzheimer's disease has successfully passed preclinical trials in mice. There is nothing left – to confirm its safety and effectiveness in humans. The study report is published in the journal Alzheimer's Research and Therapy (Davtyan et al., Testing a multistep-based combination vaccine to reduce Aß and tau pathology in Tau22/5xFAD bigenic mice).
The authors of the work, mainly representing the California Institute of Molecular Medicine, created a combination of two vaccines, called AV-1959R and AV-1980R, the first of which has beta-amyloid protein aggregates as its target, and the second – tau protein filaments.
The vaccine was tested on genetically modified Tau22/5xFAD (T5x) mice, which simultaneously demonstrated both amyloid and tau pathology.
As a result, it turned out that in mice receiving intramuscular injections of both vaccines, pathology practically did not develop and they did not show signs of Alzheimer's disease. The authors plan to start human clinical trials within two years.
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