Mice were protected from chlamydia
Scientists have created a vaccine against chlamydiaInfox
Chlamydia, which is caused by microorganisms Chlamydia trachomatis, is one of the most common sexually transmitted infectious diseases, informs those who do not know it, Infox.ru .
It is believed that chlamydia is one of the most common causes of infertility in women, this infection can also lead to ectopic pregnancy. Recently, scientists have shown that chlamydia increases the risk of developing cancer. According to Dr. Robert C. Brunham of the University of British Columbia (Canada), there are approximately 106 million cases of infection with this infection among women and men worldwide.
The creation of a vaccine against chlamydia is a dream that many scientists have been striving for, and which has not been achieved for a long time.
In the 60s, the first attempt was made. Unfortunately, it turned out to be unsuccessful: the effect of the vaccine ended in a year. Subsequent tests on primates showed that after some time after vaccination, the sensitivity to infection even increased.
A large international team of doctors led by Professor of immunology Ulrich von Andrian from Harvard University managed to move much further in creating a vaccine. However, so far its effect has been carried out on mice, and clinical trials are still far away.
Recall how vaccination affects the body.
Any vaccine is aimed at organizing the body's immune response against infection. For example, a vaccine against infectious diseases contains key proteins of a bacterium or virus that serve as antigens and trigger an immune system response. Since it turns out that the pathogen is killed or weakened, this reaction is not strong – the person does not really get sick, the symptoms of the disease may not manifest at all. But at the same time, the immunological memory will remain. When faced with a real infection, the body will be armed and able to cope with it.
As Ulrich von Adrian explains (in a press release from Harvard Medical School Safeguarding Against Chlamydia – VM), the vaccine against chlamydia must be injected into the mucous membrane, for example, through the nose, because the infection affects the mucous membrane. The new vaccine is an inactivated Chlamydia trachomatis (this microorganism is afraid of this radiation) and an auxiliary component with the help of ultraviolet examination. This component has become one of the most important achievements of scientists. It is a nanoparticle with an adjuvant, which binds to the pathogen of infection.
As the authors explain, this version of the vaccine stimulates the work of T-cells of the immune system in such a way that two waves of immunological memory are formed. Some cells from the lymph nodes are sent to the uterus, while others circulate in the circulatory system.
An experiment on mice showed that such a vaccine works effectively.
"Mice injected with such a vaccine quickly coped with the causative agent of infection. The infection disappeared faster if the animals had natural immunity after the disease," says Ulrich von Adrian.
"This is really an amazing job. Now this vaccine gives very good protection, moreover, from different strains of chlamydia," the professor adds.
An article by scientists on the development of a new vaccine against chlamydia (Stary et al., A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells) was published in the latest issue of the journal Science.
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19.06.2015