Suppress aggression
New therapy dramatically reduces the growth of aggressive prostate cancer
Svetlana Maslova, Hi-tech+
Preclinical experiments have shown the potential of combined experimental therapy against the most aggressive form of the disease — castration-resistant prostate cancer. So far, KRPJ often leads to a fatal outcome. The new results may change the situation in the future for hundreds of thousands of patients who, due to the lack of effective treatment options, are transferred to palliative care.
German scientists have presented new evidence in favor of the effectiveness of CRPC therapy with cyclin-dependent kinase inhibitors (cyclin-dependent kinase, CDK) 8 and 19, writes EurekAlert. It is known from previous studies that CDK8/CDK19 play an important role in gene transcription: through phosphorylation of specific peptides, they participate in immune-oncological processes, as well as in the transmission of cancer-related signals. Now it has been established that CDK8 and CDK19 affect the metastatic potential of tumor cells, so scientists have tested several new inhibitors on aggressive cancer models.
The combined use of CDK8/CDK19 inhibitors with the antiandrogen bicalutamide showed the most significant effect: the viability of cancer cells sharply decreased, their ability to migrate and form secondary cancer foci was blocked.
Article by Offermann et al. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer published in the American Journal Of Pathology – VM.
"This means that dual therapy can be a promising approach to overcome resistance, which often leads to death," the authors said. Scientists are continuing research that will unlock the potential of treatment for humans. They also plan to study the properties of new molecular pathways as additional therapeutic targets.
Earlier, scientists from Austria presented another way of prostate tumor metastasis. First of all, their discovery will help to diagnose the aggressiveness of cancer in time and determine the most effective treatment options in advance.
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