The cure for sarcopenic obesity

One drug helps to lose weight, build muscle and become stronger

Svetlana Maslova, Hi-tech+

These and other improvements in health indicators turned out to be under the power of only one chemical compound, which was successfully tested in preclinical studies. The drug fights a whole complex of age-related disorders that are usually observed in people after 60 years.

Loss of muscle mass on the background of obesity usually does not cause serious concern at a young age, however, as we age, this condition, called sarcopenic obesity, increases the risks of falls, stroke, cardiovascular diseases and premature mortality. Scientists from Louisiana State University has shown that the chemical compound VAM15 can cope with these problems.

Article by Dantas et al. Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control published in the Journal of Cachexia, Sarcopenia and Muscle – VM.

The effect of VAM15 is to reduce the efficiency of mitochondria, which as a result begin to burn more energy. Experiments on old mice with obesity showed that VAM15 helped them lose weight, while increasing muscle mass, strength and reducing signs of inflammation in the body. All these results were achieved even with a diet with a high fat content.

On average, mice lost more than 20% of body fat, muscle mass increased by 8%, and strength – by 40%.

Preventing and slowing sarcopenic obesity can significantly improve the quality and life expectancy of people, so the results obtained may have promising implications for clinical practice. Further studies should confirm the potential and safety of therapy for humans.

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