Without unnecessary biopsies
Prostate cancer and its aggressiveness can be determined by urine analysis
Svetlana Maslova, Hi-tech+
The scientists said that their initial diagnosis will reduce the number of unnecessary biopsies by 35%. However, more importantly, the new test shows the risks of cancer aggressiveness. This indicator is very important for monitoring the condition and choosing the optimal therapy.
Article by Connell et al. Integration of Urinary EN2 Protein & Cell-Free RNA Data in the Development of a Multivariable Risk Model for the Detection of Prostate Cancer Prior to Biopsy is published in the journal Cancers – VM.
The prostate tumor develops very slowly, but so far doctors cannot predict in which patients the cancer will begin to grow aggressively. In addition, there is a problem of overdiagnosis when, due to a not very accurate blood test for PSA (prostate-specific antigen), men are prescribed an invasive biopsy to clarify the diagnosis.
To solve this problem , scientists from The University of East Anglia has developed a new urine test ExoGrail, which is based on the discoveries of previous studies, according to a press release New prostate cancer urine test shows how aggressive disease is and could reduce invasive biopsies. The test evaluates the level of the EN2 protein and the expression of ten genes. All of them were previously associated with prostate cancer risks.
Accuracy was assessed among 207 patients who had previously had a biopsy. The test showed exactly which patients had cancer and which were healthy. These results will reduce the number of unnecessary "clarifying" biopsies by 35%, the authors estimated.
In addition to determining cancer, the dough shows how aggressively the disease is developing.
This information is very important for the patient and the doctor and allows you to choose the right treatment in the shortest possible time. So far, the authors do not report on the expected timing of the introduction of the test into clinical practice.
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