Cellular hydrogel

"Welding" of stem cells will help heal chronic wounds

Sergey Kolenov, Hi-tech+

Thanks to the modification of the membranes, the researchers connected the stem cells into a single matrix. It not only heals more effectively, but also resists rejection much better.

Scientists from the University of Bristol have developed a new technology that will become the basis for the treatment of chronic wounds. The researchers modified the stem cell membrane and connected them together.

Article by Deller et al. Artificial cell membrane binding thrombin constructs drive in situ fibrin hydrogel formation is published in the journal Nature Communications.

At the first stage, the team added the enzyme thrombin, which is involved in wound healing, to the cell membrane of mesenchymal stem cells. Then they were placed in a solution containing the blood protein fibrinogen. As a result, the cells joined into a single three-dimensional structure that can be used for tissue engineering.

The single matrix that the cells have formed will allow them to resist the aggressive environment in which they find themselves after transplantation. Until now, this has been one of the main obstacles in the development of cell therapy.

Membrane modification is not used in cell therapy for the first time. Previously, with its help, scientists gave stem cells resistance to immune attacks and low oxygen levels, as well as the ability to adhere. In addition, enzymes that accelerate wound healing can be introduced into the membranes.

Researchers from the USA have developed a polymer with shape memory, which is transformed by the action of enzymes. The new material is also suitable for wound healing, as well as for creating drugs that are activated in a specific state of the body.

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