Sochi 2014: Genetics of aging and longevity
III International Conference "Genetics of Aging and Longevity"
On April 6-10, 2014, Sochi will host an event that can change the life of every person – the international conference "Genetics of Aging and Longevity".
The conference participants will convincingly show that aging is a painful condition associated with a huge number of diseases that require treatment. Aging researchers will talk about the yet unpublished results of experiments, show real prospects for pharmaceutical companies in the development of geroprotectors with therapeutic effect for cardiovascular, neurodegenerative and oncological diseases.
Objectives of the conferenceGet a slice of modern knowledge in the field of mechanisms of aging and longevity and methods of anti-aging
- To stimulate international collaborations
- To introduce investors to leading experts in the field of aging and longevity
- To give an incentive and fame to private initiatives and foundations in the field of radical life extension
Main topicsLongevity genes in humans and animals
- Epigenetic mechanisms of aging
- Environment, genes and aging
- Biomarkers of biological age
- Pharmacological interventions in aging
- Genetics of regeneration
- Systems Biology in aging research
We are proud that scientists with an impeccable scientific reputation will speak at our conference. We want to inspire many young scientists to solve the most important task in the history of mankind – the victory over aging. We hope to join forces so that the means of slowing down aging are developed as quickly as possible.
The conference will be attended by the largest experts from the USA, Europe and Russia on the genetics of aging and life expectancy, the study of the nature of cancer and age-dependent diseases, the study of longevity and mathematical modeling of life expectancy.
Conference ParticipantsBrian Kennedy is President of The Buck Institute for Research on Aging, California, USA.
This scientific center is a recognized world leader in the field of fundamental and applied research of aging. In 20 laboratories of the Institute, geroprotective drugs are being developed and tested using the latest technologies, as well as drugs for the prevention and treatment of age–dependent diseases (oncological, cardiovascular, diabetes, etc.). Brian Kennedy is one of the leading experts in the field of aging biology, also known for his research conducted jointly with Leonard Guarante at the Massachusetts Institute of Technology, the results of which showed that sirtuins (Sir2) modulate aging.- David Gems is the C. elegans Aging Laboratory of the Institute of Healthy Aging at University College London (C.elegans aging Lab, Institute of Healthy aging UCL), United Kingdom.
Researcher of the role of genes in limiting life expectancy and the aging process on the model of the roundworm C. elegans (nematodes). The genome of C. elegans is fully sequenced, and the lifespan is 2-3 weeks, which makes this worm an ideal object for genetic manipulation in order to prolong life. David Gems is the discoverer of many longevity genes. In the experiment, worms with some mutations live 5 times longer compared to ordinary representatives of the species. - Nir Barzilai is the Director of the Institute of Gerontology at Albert Einstein College of Medicine, Bronx (USA).
The main topics of his research: the disclosure of the genetic component of aging in humans prolonging life. He is known for the research of super-long-livers (people over 100 years old) in the framework of the Longevity Genes Project ("Longevity Genes"). The results of the project showed that people with a certain set of genes age more slowly than others, age-dependent diseases begin with them on average 30 years later, and proceed less long and less painfully. - Jan Weig – Department of Genetics of Albert Einstein College of Medicine (Albert Einstein College of Medicine, Department of Genetics), New York, USA.
The research of the laboratory of Jan Weig is devoted to genomic instability and the mechanisms of its induction. It has been shown that over time, a large number of DNA damage accumulates in the cell and that this process is tissue-specific. For example, in the brain, unlike the liver, the frequency of mutations is less and does not increase with age. The consequences of genomic instability are gene expression disorders leading to cancer and aging traits. Jan Veig is the author of the famous book "Aging of the genome". - Judy Campisi – Department of Cancer Research and DNA Damage Responses, Department of Life Sciences, Lawrence Berkeley National Laboratory, Buck Institute for Cancer Research (Cancer & DNA Damage Responses Department, Life Science Division, Lawrence Berkeley National Laboratory, Buck Institute for Age Research), Berkeley, USA.
The laboratory of Professor Judy Campisi conducts multilateral research on the mechanisms of aging, specializing in elucidating the molecular causes of cell aging and cell death. Judy Campisi's work on the mechanisms of cellular aging and the role of telomeres and telomerassociated proteins in maintaining genome stability brought her worldwide fame. Currently, she and her collaborators are studying the reaction of cells to various stressful stimuli that can cause cellular aging. Such stimuli include telomere dysfunction, damage to non-telomeric DNA sites, excess signals for cell division, disruption of chromatin organization, etc. - Claudio Franceschi – Department of Experimental Pathology of the University of Bologna (Department of Experimental Pathology, University of Bologna), Bologna, Italy.
The main focus of Claudio Francesca's research is the role of the immune response in the occurrence of cancer and in human aging. The study of centenarians who managed to avoid cancer and heart disease is one of the promising approaches in this direction. Claudio Franceschi and his colleagues investigated why some people manage to live up to 100 years without getting cancer. It turned out that centenarians have increased activity of anti-inflammatory cytokines such as IL-10 and TGF-beta, as well as a reduced response to IGF-1. Currently, Claudio Franceschi is one of the leading researchers in the European project "Genetics of Healthy Aging in Europe" (Genetics of Healthy Aging, GEHA). This project includes 24 organizations from European countries plus the Beijing Genome Institute in China. The objective of the project is to search for genes responsible for healthy longevity. - Robert Schmuckler Rees – Department of Gerontology, University of Arkansas for Medical Sciences (Departments of Geriatrics, University of Arkansas for Medical Sciences), Littlerock, USA.
One of the directions of Professor Schmuckler-Rees' research is the search for genes regulating the lifespan of the nematode C. elegans. In his laboratory, nematode mutants were created by the age-1 gene, in which the catalytic subunit of phosphatidininositol-3-kinase (PI3K(CS)) was cut out, having a tenfold increased lifespan. These nematodes have a much longer period of development, normal mobility, however, mutant animals have to sacrifice body size and metabolic rate. Also, these worms have exceptional resistance to oxidative and electrophilic stresses compared to worms in the control group. - Richard Miller – Department of the Center of Pathology and Geriatrics, University of Michigan (Department of Pathology and Geriatrics Center, University of Michigan), Michigan, USA.
The laboratory headed by Richard Miller was one of the first to show the effect of rapamycin on increasing life expectancy in mammals. Rapamycin is able to inhibit the mTOR signaling pathway, its use causes a 10% increase in life expectancy in experimental mice. This is one of the first works that showed the possibility of targeted pharmacological intervention in increasing life expectancy. - Andrey Gudkov – Roswell Park Cancer Institute, USA.
He founded Cleveland BioLabs (NASDAQ: CBLI), a company that produces cancer drugs and bioprotective drugs based on his own inventions. Author of more than 160 scientific papers in the field of oncology, virology, molecular genetics and radiation biology. Holder of American and international patents. One of the most successful Russian biologists working abroad. - Elena Pasyukova – Institute of Molecular Genetics of the Russian Academy of Sciences (RAS), Moscow, Russia.
He is engaged in the identification of genetic determinants that determine the life expectancy of Drosphila melanogaster. As a result of large-scale screening, which involved more than 1,000 mutant lines, 58 previously undescribed mutations affecting the increase in life expectancy were identified. It was also possible to identify a common transcription profile characteristic of long-lived flies. The model system of the fruit fly used by Elena Pasyukova and her colleagues allows us to study the complex contribution and interaction of genes in determining longevity. - Walter Longo – Leonard Davis School of Gerontology, University of Southern California, Davis, USA.
The creator of a genetically modified strain of yeast fungus capable of living 10 times longer than usual. To achieve the result, the scientists used a combination of two techniques: they turned off certain genes (Ras2, Tor1 and Sch9) in the cells and put the cells on a low-calorie diet. The researchers also found that serine threonine kinase Rim15 is needed to prolong the life of yeast. - Anatoly Yashin – Center for Population Health and Aging, Duke University, Durham, USA.
A scientist engaged in statistical analysis and mathematical and computer modeling of genetic and demographic data related to aging. The field of interests is the use of biomarkers of aging to predict the likely life expectancy, as well as the interaction of genetic and non–genetic factors in determining life expectancy. Currently, the group headed by Anatoly Yashin has developed new methods for analyzing population multifactorial genetic data, which are used in longitudinal studies.
Download the full press release with photos of the lecturers.
Websites: http://www.scienceagainstaging.com , http://aging-genes2014.comPhone of the organizing committee: +7(925) 514-38-19
Email: aging@ib.komisc.ru , a.v.perfilyev@gmail.comPortal "Eternal youth" http://vechnayamolodost.ru