Alzheimer's disease: two new targets
A new study has identified two potential targets for the development of future drugs that the authors hope will increase the effectiveness of treatment of patients with Alzheimer's disease.
12.09.2013A new study has identified two potential targets for the development of future drugs that the authors hope will increase the effectiveness of treatment of patients with Alzheimer's disease.
12.09.2013Identification of long–lived proteins, which may be the weakest link of the aging proteome – a set of proteins expressed by the genome under given environmental conditions - will help to understand the molecular basis of aging.
11.09.2013In a young cell, pairs of protein complexes of ATP synthase are located close to each other and, due to this, bend the mitochondrial membrane, forming folds. Over time, there are fewer such pairs, and instead of a complex structure, the membrane turns into a relatively smooth two-layer bubble.
09.09.2013Now the tests of "Antistarin" on animals are continuing. Then the developers plan to start its release as a veterinary remedy and hope that in the future the results of research will allow us to start treating people.
06.09.2013The alkaloid contained in the leaves and fruits of the areca palm "rejuvenates" worms by improving the condition of their motor neurons and, accordingly, slowing down muscle aging.
05.09.2013After two weeks of playing, the ability to solve several tasks at once in people aged 60-85 reaches the level of untrained twentysomethings. However, the data obtained do not answer the question: can this method prolong active life?
05.09.2013The notorious protein sirtuin, as it turned out, really prolongs youth – however, for this it needs to be in certain areas of the hypothalamus, the main endocrine regulator of the body.
05.09.2013An important role in the physiological aging of the cell belongs to epigenetic factors affecting chromatin – the structure that ensures the ordering of genetic material in the nucleus.
03.09.2013The addition of two polyamines to the diet of drosophila – spermidine and putrescine – prevents age-related memory deterioration. The researchers believe that their results can be transferred to humans with some caution.
02.09.2013By suppressing the activity of the mTOR gene, scientists extended the life of mice by about 20%, which corresponds to an increase in the average life expectancy of a person by 16 years.
02.09.2013Researchers from the University of Naples have shown that statins – drugs widely used to lower cholesterol levels in the blood – are able to slow down the aging process by reducing the rate of telomere shortening.
02.09.2013He has every reason to do so: firstly, the strength of memory depends on its presence in neurons, and secondly, its level decreases with age, which may explain the senile weakening of memory.
30.08.2013Maybe it's really time to get used to the fact that, as Katerina Tikhomirova said in the film "Moscow does not believe in tears", "life is just beginning at 40"?
30.08.2013It was found that it is possible to reduce the intensity of age-related skin changes and improve wound healing processes by inhibiting the activity of the enzyme 11beta-HSD1.
23.08.2013Scientists have shown for the first time that the aging process occurs not only as a result of the accumulation of mutations in mitochondrial DNA during life. Mutations inherited from the mother can accelerate the aging process.
22.08.2013Dutch and American researchers studied the data of about 30 thousand diabetics aged 60 years and older over a ten-year period. They found 8 factors that most often precede the development of senile dementia.
21.08.2013If it is possible to isolate a damaged gene from patients, in addition to many unpleasant consequences that look decades younger than biological age, it can be used as a target for drugs that slow down aging.
20.08.2013For patients over 75 years of age with a diagnosis of acute coronary syndrome, half a dose of a modern antiplatelet is as effective as a whole dose of a traditional drug.
20.08.2013Researchers from the Stanford University School of Medicine have proposed a fundamentally new hypothesis of the causes of Alzheimer's disease.
16.08.2013HLH-30 is the first transcription factor functioning in all known autophagy-dependent paradigms of longevity, which strengthens the position of the new concept that autophagy contributes to an increase in life expectancy.
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