Gerontology

How do planarians ensure their immortality

One could say that planarians fit into the theory that only organisms with asexual reproduction can afford immortality. But those worms that reproduce sexually are also capable of endless regeneration.

To prolong your life, ask for SIRT6 supplements

The lifespan of male mice with an additional copy of the SIRT6 gene increased by 10-17%.

Don't let the cells age – think about the troubles tomorrow

Those who worry more before a stressful event age faster at the cellular level. This is expressed in the shortening of telomeres, counters of cell division, which are considered indicators of biological age.

Two Simple Ways to Grow old and Die Prematurely

Smoking and obesity "age" the body at the molecular level in the same way as time does.

Preserve youth: stem cells instead of physical education

The ability of adult stem cells to actively respond to mechanical impact will help develop new methods of rehabilitation after injuries and prevent age-related loss of muscle mass, and possibly for its recovery.

Grow old actively!

This paper outlines several approaches used to determine active aging, and also explains the dangers associated with some of the generally accepted concepts.

Grow old actively: used literature

References to the article Boudiny & Mortelmans A Critical Perspective: Towards a Broader Understanding of ‘Active Aging' (Critical Perspective: to expand the understanding of the term "active aging").

Cells age because of long-lived proteins

Extremely long-lived proteins in the composition of nuclear pores work all the life of the body without replacement. Violations of their structure make the membrane of the cell nucleus permeable to toxins, and the normal operation of the cell is disrupted.

Forever young and forever drunk

The main rules for prolonging youth with alcohol: take a little, but regularly, start from the first days of life, do not snack and ... be born a worm.

The probability of living to a hundred years was calculated by genes

A mathematical model of the relationship between certain gene variants and life expectancy makes it possible to determine whether the "owner" of a given genome will be able to celebrate the centenary, with a probability of 60 to 85%.

Rejuvenation of the membranes of aging nerves: and here young blood will help

As a result of the experiment on connecting the blood flows of old and young mice, the remyelination of the nerve sheath in elderly rodents began to go as well as in young animals.

Probiotics increase life expectancy

If the results of clinical studies confirm the data of experiments on mice, probiotic bacteria of the LKM512 strain will help to increase human life expectancy and improve the health of the elderly.

Young stem cells slow down aging

The introduction of young stem cells did not lead to a complete cure of progeria in mice, but perhaps the results obtained will help develop ways to prolong life with normal aging.

Life extension: resveratrol, spermidine and autophagy – references

Life extension: Resveratrol, spermidine and autophagy (3)

The final confirmation of the hypothesis about the relationship between increased autophagy activity and healthy aging of mammals, especially humans, would revolutionize the entire field of research on aging mechanisms.

Life extension: Resveratrol, spermidine and autophagy (2)

Induction of autophagy with the help of pharmacological agents can increase the duration of a healthy life. It is very likely that autophagy not only protects cells, but also slows down aging at the organizational level.

Life extension: Resveratrol, spermidine and autophagy (1)

Autophagy is traditionally considered a mechanism of self-destruction of cells, but there is more and more evidence that the launch of autophagy is necessary for the implementation of cytoprotective and /or aging-slowing effects of spermidine and resveratrol.

How a low-calorie Diet Slows down Brain Aging

The fact that fasting prevents the aging of the brain and the development of Alzheimer's, Parkinson's and many others has been known for a long time, but the molecular mechanism of this dependence remained unclear. It looks like it's starting to clear up a little bit now.

Low-calorie diet, life extension and AMP-dependent kinase

In addition to the previously known mechanisms, the effect of prolonging life with a low-calorie diet is also due to the activation of AMP–dependent kinase, an enzyme that promotes the normal completion of cell division.

Why do eggs age so quickly?

All the efforts of eggs are spent on protecting DNA, and due to the fact that they do not particularly monitor their own condition, oocytes age much faster than somatic cells.