Why do muscles age and how to deal with it
Researchers from the USA and Denmark have identified the main causes of muscle weakness in the elderly and have shown that the natural aging process of muscle tissue can be slowed down.
01.10.2009Researchers from the USA and Denmark have identified the main causes of muscle weakness in the elderly and have shown that the natural aging process of muscle tissue can be slowed down.
01.10.2009Unfortunately, the creation of effective "medicines for old age" is still far away. Rapamycin has many side effects and therefore cannot be used to prolong people's lives. In particular, it has an immunosuppressive effect (weakens the immune defense of the body).
16.07.2009There is no question of transferring the results to clinics yet. But the value of the discovery is already great enough: it has allowed scientists to advance in understanding the links between immunity and longevity.
13.07.2009The prospects are tempting: one injection of a genetically engineered vector with WWP1 will be enough to prolong life by 20%, and at the same time get rid of many age-related diseases. But this is only if scientists manage to achieve the same effect on mammals.
13.07.2009Sirtuins at the cellular level maintain the integrity of the genome, increase resistance to adverse factors and resist physiological aging. Scientists from the Wistar Institute for the first time demonstrated the molecular target of one of the representatives of this class of proteins, Sir2, in the process of regulating the aging of yeast cells.
17.06.2009Unlike many other resources of this kind, the AnAge database includes only scientifically confirmed data. The database contains information about the maximum life expectancy of 3,650 vertebrate species (humans are in 11th place among them), as well as body weight, growth and puberty rates, reproduction rate and other characteristics that can be used for comparative studies.
16.06.2009Experiments with increasing life expectancy led to an unexpected result: all cells of long-lived mutants acquired the properties of sexual.
15.06.2009In Alzheimer's disease, "prion traits" were found – when introduced into the brain, a mutant tau protein turns into a similar normal tau protein.
08.06.2009Reactive oxygen species, the harm of which mountains of scientific articles have been written about, turned out to be just as necessary for the body as, for example, cholesterol. A small but constant dose of free radicals is exactly what helps the body cope with premature aging.
02.06.2009One of the acute problems of modern healthcare is the increase in the frequency and severity of age–related diseases, in particular Alzheimer's disease and type II diabetes. It is assumed that these diseases may be interrelated. But are Alzheimer's disease and diabetes a natural stage of cell aging or a consequence of the influence of harmful factors characteristic of modern life – overeating, stress and a sedentary lifestyle?
14.05.2009If you have a relative who gave birth to a child after 45 years, then perhaps your family has a good inheritance that promises you a long life.
04.05.2009Measuring the level of beta-amyloid protein and tau protein in the cerebrospinal fluid allows you to accurately predict the likelihood of developing Alzheimer's disease. And as a result of taking an experimental drug, the SAP protein disappeared in the brain of patients, which, according to doctors, is one of the causes of Alzheimer's disease: it protects amyloid plaques from recognition by the immune system.
16.04.2009Analysis of the interaction of proteins regulating aging has shown that their functions and changes in their activity during life are very similar in humans and in simple organisms.
19.03.2009The main source of energy and carbon for heterotrophic organisms is glucose, but its excess is associated with the aging process, and its lack slows it down. Scientists from the University of Montreal have discovered that life expectancy is influenced not by the metabolic processes occurring with glucose in the cell, but by the cell's feeling of its amount outside.
18.03.2009Different protocols for limiting the diet of C. elegans prolong the life of this organism through different molecular pathways. Knowledge of the relative effectiveness in the fight against senile diseases and the molecular mechanisms of various types of dietary regimens may help in the future in the development of pharmacological drugs to increase life expectancy.
18.03.2009As a cell ages, the quality control mechanism of its proteins changes. Researchers from the Institute of Pathological Chemistry at the University of Mainz have identified control proteins that at the molecular level regulate both potential cellular protein degradation pathways - proteasomal and lysosomal.
16.03.2009First gray, and then white hair is the result of the accumulation of hydrogen peroxide in the hair follicles. By old age, the amount of peroxide in each hair can be measured in milligrams, that is, it makes up a significant fraction of the hair mass.
24.02.2009Women live longer due to the presence of a second X chromosome, which can insure against hidden mutations on the first one. To test this, Swedish scientists tracked 10 generations of siblings who mated exclusively with each other.
06.02.2009Representatives of the sirtuin family take part in the aging of the body and the occurrence of age-related diseases. The SIRT6 protein is involved in maintaining genome stability and protecting telomeres, as well as regulating gene expression. Another pathway is associated with the protein NF-kB, which attaches to and controls the expression of many genes, including genes involved in aging.
06.02.2009A new model of Alzheimer's disease puts its origin in direct connection with the sclerosis of blood vessels feeding the brain. When the lumen of these arteries is closed by fatty deposits, the brain begins to receive less blood and, consequently, less glucose. It turns out that arteriosclerosis is not only responsible for vascular dementia, but also provokes Alzheimer's disease.
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