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ABC magazine based on EurekAlert materials! –
Molecule produced during exercise boosts brain health

A group of scientists led by Dr. Bruce Spiegelman from the Dana-Farber Cancer Institute and Harvard Medical School found that physical activity has a positive effect on the brain.

Physical education leads to an increase in the concentration of irisin protein in the brain, which has a neuroprotective effect.

It is known that physical activity can lead to improved cognitive functions and suppression of symptoms of neurological diseases – for example, depression and Alzheimer's disease. The mechanism of formation of such a relationship has not been studied well enough until recently, but researchers believed that the key role in this process belongs to the neurotrophic factor of the brain (BDNF).

Experiments on mice revealed that sports activities lead to an increase in the expression level of the FNDC5 protein and its hydrolysis product, irisin, as well as to an increase in the expression level of BDNF and activation of genes responsible for cognitive functions. In a line of mice with low irisin levels, BDNF expression was also reduced.

The researchers plan to develop a stable form of irisin that can be injected into mice to stimulate mechanisms that prevent brain degeneration.

The article Exercise Induces Hippocampal BDNF through a PGC-1alfa/FNDC5 Pathway is published in the journal Cell Metabolism.

Portal "Eternal youth" http://vechnayamolodost.ru 15.10.2013