NAD+ will rejuvenate the liver and kidneys
NAD+ (nicotinamide-adenine-dinucleotide) is a coenzyme, that is, it helps enzymes to carry out their functions. This molecule participates in many different processes in the cell, thus taking part in the vital activity and energy turnover in the cell.
Recent studies have shown that with age, the level of NAD+ production in the human body decreases, and if you restore the "young" level of production of this molecule, you can prolong not only life, but also health.
A group of scientists published in the journal Nature the results of the work, which describes a new way to increase the production of NAD + in the liver and kidneys. It consists in blocking the action of the ACMSD enzyme specific to these organs (its full name takes one and a half lines), responsible for stopping the production of NAD +. It is noteworthy that this mechanism, apparently, is very conservative, i.e. it has not undergone significant changes in the process of evolution – scientists were able to reproduce the results on two different model animals: nematodes Caenorhabditis elegans and mice. In both cases, in response to the blocking of ACMSD, there was an increase in the production of NAD+. In addition, blocking the function of this enzyme leads to an increase in the activity of the SIRT1 protein from the sirtuin family, which in turn stimulates the mitochondria.
In their work, the researchers used two potential selective ACMSD blockers developed by TES Pharma. Since ACMSD is produced only in the liver and kidneys, we can talk about the potential protective properties of the tested inhibitors – both of them have demonstrated the ability to preserve kidney function in case of damage and liver in non-alcoholic steatosis.
Thus, the role of the ACMSD enzyme in the production of NAD+, the activity of sirtuins, as well as the work of mitochondria is shown. Scientists hope that their discovery will help patients suffering from liver and kidney diseases.
Article by Katsyuba et al. De novo NAD+ synthesis enhances mitochondrial function and improves health published in Nature.
Anastasia Poznyak, portal "Eternal Youth" http://vechnayamolodost.ru / based on the materials of ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE EPFL: Anti-aging molecule NAD+ gets a boost from blocking an enzyme.