"Pills for old age" are getting closer to clinical research

The American company Sirtris Pharmaceuticals is not happy with the unusual results of independent laboratory testing of its new drug SRT1720, informally referred to as "pills for old age". In short, the bottom line is this: eat as much as you want, stay slim and increase your athletic performance – at the same time.

SRT1720 activates the same receptors in cells as the repeatedly studied compound resveratrol, which, as experiments have shown, prolongs the life of obese mice (and not only them) and makes rodents more resilient.

And it is noteworthy that these are the same SIRT1-type receptors, which, as previously shown, are activated (and activate the gene of the same name) when reducing calorie intake, causing the effect of prolonging life in both mice and humans.

I must say that SRT1720 is being tested primarily as a treatment for type 2 diabetes and some diseases associated with aging (for similar purposes, scientists have been studying the effect of resveratrol for years). However, its effect on the body seems to be much broader.

Preclinical testing of the drug was conducted by scientists from the Swiss Federal Polytechnic Institute in Lausanne (EPFL) and a number of other institutes. They monitored the condition of two groups of mice (subjects and controls), which were overfed by 40% over the norm, provoking an increase in excess weight. The test group was also divided into two parts: they were regularly given SRT1720 in two dosages – 100 and 500 milligrams.

After 15 weeks of intensive feeding, the mice from the control group became noticeably obese and lazy. They could only run continuously for half a mile (800 meters). The animals from the "100 mg group" felt much better, demonstrating the result of running 0.7 miles, and the animals who received a shock dose of the drug ran for a whole mile. At the same time, the last mice also differed from representatives of other groups in that they did not gain excess weight at all, despite the increased diet. In addition, animals from two experimental groups showed normal cholesterol levels in the blood against mice from the control group.

That is, this drug reproduced the rejuvenating effect of reducing nutrition with an actual increase in the latter! However, so far no side effects from the use of SRT1720 have been identified.

But the main thing is that the researchers claim that the effect of this drug is 1000 times stronger than that of resveratrol. (By the way, in order to get a significant amount of the last healing compound from red wine, where there is a lot of it, you need to drink dozens of bottles a day, which deprives such a "prolongation of life" of any meaning, since it is interrupted by the destructive effects of alcohol.)

The results of the experiment (Jerome N. Feige et al., Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation) are published in the journal Cell Metabolism. Later, scientists intend to test the drug on humans.

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Portal "Eternal youth" www.vechnayamolodost.ru11.11.2008