10 October 2022

"Plastomitin": wait 10 years

In Russia, in the next ten years, they plan to launch the production of anti-aging drugs



Russian scientists have developed and completed the first phase of clinical trials of an anti-aging drug that increases the duration and quality of life. Completion of the full test cycle and market entry is expected within a decade, Dmitry Vilensky, Deputy Dean of the Faculty of Bioengineering and Bioinformatics of Moscow State University, told TASS on the sidelines of the IN'HUB forum in Novosibirsk.

"I would expect that in the next ten years [the drug will be available], now it will be more difficult both in terms of development and production of reagents and everything else," Vilensky said, specifying that the development is being carried out by the Ion Skulachev project at Lomonosov Moscow State University under the leadership of Academician Vladimir Skulachev.

Vilensky clarified that during preclinical tests it was shown that the drug called "Plastomitin" prolongs the life of animals. The effect is shown on mice, yeast, fruit flies, fish, dogs, rabbits. The results depend on the dosages, conditions of animal keeping. He added that in mice who received the drug with water for life, the indicators of aging markers were significantly better than in mice from the control group. "At the moment, many diseases that are associated with old age have already been tested on animals. There are a lot of things, and all this leads to the fact that we can slow down aging on animals," Vilensky said, adding that the drug has also shown its safety on different types of animals.

At the lecture "Biological aging. Is it possible to create a drug to prolong youth?" during the IN'HUB innovators forum in Novosibirsk, Vilensky said that one of the hypotheses of the causes of aging is that aging is inherent in living organisms evolutionarily, and at a certain point in life the human body begins to actively synthesize dangerous substances, poisoning itself. "We are able to synthesize a huge amount of poisons <...>, one of the very harmful substances that is produced inside us is free radicals. In mitochondria – the main production of free radicals. And what is most interesting, the more this poison is produced, the older a person is, this poison increases with age, and aging then is a slow poisoning of the body, which occurs due to free oxygen forms," he explained, adding that under the action of free radicals, a whole cascade of reactions is triggered – the number of cells decreases, atrophy begins the quality of muscle tissue decreases, necrosis, damage and inflammatory processes begin.

Under the leadership of Academician Vladimir Skulachev, the substance SkQ1 was developed – it is a powerful antioxidant that is able to penetrate into the mitochondria and fight free oxygen forms directly at the place of their production. "It works as a classic antioxidant, it binds free radicals, neutralizes – unlike banal antioxidants, it is reusable," Vilensky said.

According to him, on the basis of SkQ1, Visomitin eye drops have already been developed and are available on the market, which also fight aging, Exomitin wound healing ointment and MitoVitan cosmetics. In addition, eye drops are being tested in other dosages, and the third phase of eye drops research is currently taking place in America. "This is nonsense for medicines invented in Russia," Vilensky said, adding that all developments and drugs are patented.

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