08 July 2011

References to the article "The Mystery of longevity"

The literature used in the article Mikhail V. Blagosklonny
Why human lifespan is rapidly increasing: solving “longevity riddle” with “revealed-slow-aging”
(Why human life expectancy is increasing rapidly: solving the "mystery of longevity"
using the hypothesis of "manifested slow aging"
)

1. Blagosklonny MV. Validation of anti‐aging drugs by treating age‐related diseases. Aging 2009; 1: 281‐288.

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2366‐2368.

3. Vaupel JW. Biodemography of human ageing. Nature. 2010; 464: 536‐542.

4. Oeppen J, Vaupel JW. Demography. Broken limits to life expectancy. Science. 2002; 296: 1029‐1031.

5. Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: the challenges ahead. Lancet. 2009; 374: 1196‐1208.

6. Blagosklonny MV. Aging and immortality: quasi‐programmed senescence and its pharmacologic inhibition. Cell Cycle 2006, 5: 2087‐2102.

7. Blagosklonny MV. Aging: ROS or TOR. Cell Cycle. 2008; 7: 3344‐3354.

8. Blagosklonny MV. TOR‐driven aging: speeding car without brakes. Cell Cycle. 2009; 8: 4055‐4059.

9. Hay N,Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004; 18: 1926‐1945.

10. Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124: 471‐484.

11. Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging. 2009; 586‐597.

12. Blagosklonny MV and Hall MN. Growth and aging: a common molecular mechanism. Aging. 2009; 1: 357‐362.

13. Demidenko ZN and Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7: 3355‐3361.

14. Blagosklonny MV. Aging‐suppressants: cellular senescence (hyperactivation) and its pharmacological deceleration. Cell Cycle. 2009; 8: 1883‐1887

15. Kneissel M, Luong‐Nguyen NH, Baptist M, Cortesi R, Zumstein‐Mecker S, Kossida S, O'Reilly T, Lane H, Susa M. Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts. Bone. 2004; 35: 1144‐1156.

16. Blagosklonny MV. An anti‐aging drug today: from senescence‐promoting genes to anti‐aging pill. Drug Discovery Today. 2007; 12: 218‐224.

17. Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther. 2008; 7: 1520‐1524.

18. Elloso MM, Azrolan N, Sehgal SN, Hsu PL, Phiel KL, Kopec CA, Basso MD, Adelman SJ. Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E‐deficient mice. Am J Transplant. 2003; 3: 562‐569.

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21. Gadioli AL, Nogueira BV, Arruda RM, Pereira RB, Meyrelles SS, Arruda JA, Vasquez EC. Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E‐deficient mice. Braz J Med Biol Res. 2009; 42: 1191‐1195.

22. Zhao L, Ding T, Cyrus T, Cheng Y, Tian H, Ma M, Falotico R, Pratico D. Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor. Br J Pharmacol. 2009; 156: 774-785.

23. Mueller MA, Beutner F, Teupser D, Ceglarek U, Thiery J. Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia. Atherosclerosis. 2008; 198: 39-48.

24. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandezr E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature. 2009; 460: 392-396.

25. Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV. Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice. Am J Pathol. 2010; in press.

26. Moskalev AA, Shaposhnikov MV. Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster. Rejuvenation Res. 2009; in press.

27. Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010; 11: 35-46.

28. Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, Larsen CP, Ahmed R. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009; 460: 108-112.

29. Finch CE, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science. 2004; 305: 1736-1739.

30. Crimmins EM, Finch CE. Infection, inflammation, height, and longevity. Proc Natl Acad Sci USA. 2006; 103: 498-503.

31. Taleb NN. The black swan: the impact of the highly improbable. 2007. Random House, New York.

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08.07.2011

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