Antibiotics for superbacteria stop working too. Scientists have found a reason
Infectious bacteria exposed to the antibiotic albicidin quickly develop resistance to it.Researchers from the Free University of Berlin have shown that bacteria are able to resist the "revolutionary new type of antibiotic" albicidin. Useful and pathogenic microorganisms adapt quickly enough and develop resistance to such treatment.
Albicidin is an antibiotic produced by the bacterium Xanthomonas albilineans, which lives on sugarcane leaves. Previous studies have shown that it has a different therapeutic effect than other drugs. Albicidin inhibits (suppresses) DNA gyrase, an enzyme that promotes bacterial DNA replication and is absent in human cells.
In the first experiments, albicidin was shown to be highly effective in killing bacteria, including the superbacteria Escherichia coli (Escherichia coli) and Staphylococcus aureus (Staphylococcus aureus). So the researchers began working on creating an antibiotic based on it for extreme cases when other drugs no longer work.
In a series of experiments, the researchers from the Free University of Berlin acted with high doses of albicidin on the bacteria E. coli and Salmonella enterica (Salmonella typhimurium). The analysis showed that they rapidly acquired resistance to treatment by increasing the number of copies of the STM3175 gene in the bacterial cells' DNA. It encodes a protein that interacts with albicidin, protecting against it