Are you treating periodontal disease? Check the heart!
A genetic relationship between periodontitis and myocardial infarction was foundGerman scientists have discovered a genetic relationship between inflammation of the tissue surrounding the root of the tooth (periodontitis) and coronary heart disease (CHD).
Researchers were prompted to search for a connection between these diseases by the facts that periodontitis and coronary heart disease have similar risk factors (smoking, diabetes mellitus, obesity, male sex) and development mechanisms (imbalance of immune responses in chronic inflammation). In addition, the similarity of bacteria found in the oral cavity and in atherosclerotic plaques of the arteries of the heart was shown.
A group of researchers from the University of Kiel analyzed a section of the ninth chromosome 9p21.3, previously known for its association with the development of myocardial infarction, in 151 patients with the most aggressive forms of periodontitis and in 1097 patients with coronary heart disease who had suffered a myocardial infarction. The variants of this site turned out to be identical for representatives of both groups.
Subsequently, this result was confirmed in another 180 patients with periodontitis and 1100 patients with coronary heart disease. According to the head of the study, Arne Schaefer, the risk of both diseases is due to a section of the antisense DNA chain called ANRIL.
Based on the data obtained, the scientists recommended that all patients with periodontal disease carefully and timely monitor risk factors to prevent the development of a heart attack.