Experts have created an atlas of human kidney cells
Experts have compiled the most comprehensive atlas of human kidney cells, which contains information and three-dimensional images of healthy and damaged cells. Scientists suggest that this will simplify the identification of factors contributing to the development and progression of kidney disease and kidney failure, and will make it possible to develop new methods of their treatment.Scientists from Harvard Medical School, UCLA, the University of Michigan, Indiana University School of Medicine and Washington University, supported by the US National Institutes of Health (NIH), have developed an atlas of human kidney cells. The results of the study are published on the NIH website with reference to the journal Nature.
The atlas of kidney tissues contains information about 51 main types of kidney cells, including rare and new populations. In addition, it describes 28 cell states that correspond to cell damage or disease. The atlas also contains data on genes, interactive 3D models of cells and their microenvironment.
Scientists believe that the information presented in the atlas will allow comparing healthy and damaged kidney cells, thanks to which researchers will be able to identify factors contributing to the development and progression of kidney disease and kidney failure, and develop the necessary therapy. Interactive data visualization provides an opportunity to study normal physiology and cell differences by gender, the cascade of reactions associated with the transformation of a healthy cell into a damaged cell, clinical outcomes and disease pathogenesis, the authors said.
All of the resulting data, including 3D images and analytical tools, are available at atlas.kpmp.org.