Protein map of human saliva

American scientists have compiled a protein map (proteome) of human saliva, identifying more than a thousand proteins contained in the secret of the large salivary glands of people of different genders, ages and races. The results of the study can be used in the development of new, rapid and non-invasive tests for many dangerous diseases.

The implementation of a large-scale research project required the participation of specialists from several research centers: the University of Rochester, the Scripps Institute, as well as the University of South Carolina, the University of California at San Francisco and the University of California at Los Angeles.

The protein composition of human saliva was studied by mass spectrometry using samples taken from 23 healthy representatives of different ethnic groups. The results obtained were compared with data on proteins present in the blood and tear fluid.

To date, proteins have been found in human saliva that are markers of Alzheimer's, Parkinson's, Huntington's disease, colon, pancreatic and breast cancer, as well as diabetes. According to the researchers, the results of their work will significantly expand the list of diseases diagnosed by the protein composition of saliva.

The research report is published in the latest issue of the Journal of Proteome Research.

Source: U.S. researchers create protein map of human spit – Scientific American, 03/25/2008

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26.03.2008