A new target
Scientists of the Crimea and the USA jointly develop a new method of cancer treatment
Scientists of the Crimean Federal University and the University of Nebraska Medical Center are developing a highly effective method of treating prostate cancer using cellular and genetic technologies.
Experts have found out that the ATF6 protein synthesized by the endoplasmic reticulum plays a key role in the reproduction of cancer cells. If you block its production at the genetic level, then the growth of the prostate tumor slows down at times. Experiments have already been conducted on laboratory mice, and clinical cases among patients have been collected at St. Luke's Clinical Medical Multidisciplinary Center of KFU.
"We already know how protein mechanisms work in a simple tumor model, so now we are focusing on a detailed orthotopic model and developing a new targeted therapy. Now experiments are continuing on special knockdown mice, in which the ATF6 protein gene is initially blocked, which will help us better calculate its role in the development of the disease. Our goal is to create an inhibitor to control the production of this protein in patients. Thanks to the clinical experience of the staff of the Crimean Federal University, various stages of the disease and mechanisms of prostate cancer development are being evaluated," said Armen Petrosyan, PhD, Professor of the Department of Biochemistry and Molecular Biology at the University of Nebraska Medical Center.
To date, genetic cancer drugs have many side effects, and reagents that block the gene are easily destroyed in the liver. Therefore, researchers strive for protein management, and the use of genetic tools allows for a more detailed study of the consequences and effectiveness of blocking ATF6, the press service of the KFU reported. Vernadsky. Based on the research results, a scientific article "The non-canonical mechanism of ER stress-mediated progression of prostate cancer" was published in the international journal "Journal of Experimental and Clinical Cancer Research", which is part of the Scopus abstract database.
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