19 March 2018

Pills for men

At the 100th Annual Meeting of the Endocrinological Society ENDO 2018, which is taking place in Chicago these days, the results of a study of a new oral contraceptive for men were reported.

The drug DMAU (dimethandrolone undecanoate) combines the effects of the male sex hormone testosterone and the female – from the progestin group. It must be taken once a day.

Work on the creation of a contraceptive for men has been going on for a long time, but so far it has not been possible to create a safe remedy. Forms of testosterone for oral administration have a damaging effect on the liver. In addition, they are excreted from the body too quickly, so they require taking at least twice a day. DMAU is devoid of these disadvantages due to the presence of undecanoate, a long–chain fatty acid, in its composition.

Stephanie Page and her colleagues from the University of Washington conducted a study of an experimental drug, which involved 100 healthy men aged 18 to 50 years. The tested doses were different: 100, 200 and 400 mg. Each of the three groups consisted of five people who were randomly assigned to receive a placebo, and 12-15 people who received an active drug. Each subject received one tablet a day with meals for 28 days.

The study was completed by 83 people. Each of them gave a blood sample twice (at the beginning and end of the study) to analyze the hormonal background, cholesterol levels and other parameters.

In the group of men who received a high dose of DMAU (400 mg), there was a moderate suppression of the synthesis of testosterone and two more hormones that are necessary for sperm production. According to previously conducted long-term studies, such suppression of sperm production provides an effective contraceptive effect.

Despite the decrease in testosterone levels, the study participants did not notice any symptoms characteristic of a deficiency of male sex hormones.

The drug also had side effects: all the subjects who took DMAU gained weight, and the level of "good" cholesterol – high-density lipoproteins - decreased in their blood. But these phenomena were poorly expressed. The levels of enzymes signaling the state of the kidneys and liver were normal.

Larger and longer-term studies of the efficacy and safety of the new drug are currently being planned.

Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru according to the Endocrine Society: Dimethandrolone undecanoate shows promise as a male birth control pill.

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