Wound healing without scarring
Chronic ischemic wounds are often found in people with conditions such as diabetes, pressure sores, arteriosclerosis, after traumatic injuries or radiation therapy. Standard methods of treating these wounds include bandages, application of healing gels and surgical intervention. Although these measures provide some relief, they often do not lead to complete healing. So, in the United States, about 7 million people have non-healing skin ulcers, so multibillion-dollar budgets are invested in finding solutions. When the disease progresses, non-healing wounds lead to amputation of limbs.
A group of researchers from the Mayo Clinic, led by plastic surgeon Stephen Moran, demonstrated the effectiveness of their innovative technique. They used a purified exosomal product (PEP) from platelets to deliver transforming growth factor beta (TGF-β), a cytokine that controls proliferation, cellular differentiation and other tissue functions.
PEP is an extracellular vesicle that naturally transfers loads from one cell to another, targeting tissues in need of repair. The powder with PEP is mixed with a hydrogel immediately before applying to the wound.
The research team reproduced ischemic wounds in rabbits, one part was treated with PEP and compared them with wounds that were treated only with hydrogel. They found that PEP treatment led to the complete closure of the defect with healthy skin without scars, regeneration of blood vessels with restoration of blood supply to tissues was noted.
The convenient powder form allows you to store PEP at room temperature for a long time. Unlike cell therapy, it does not need to be sent to an external laboratory for cultivation and scaling. This will help eliminate the logistical difficulties often seen with traditional regenerative therapy.
This work laid the foundation for FDA approval of a first-in-class clinical trial to evaluate the safety of a purified exosomal wound healing product in patients.
Article A.Shi et al. TGF-β donor exosome accelerates ischemic wound healing is published in the journal Theranostics (the link is available only for downloading the text of the article in *pdf).
Aminat Adzhieva, portal "Eternal Youth" http://vechnayamolodost.ru based on the materials of Press-News: Mayo Clinic preclinical discovery triggers wound healing, skin regeneration.